Drug-Delivery Precursor Enhancing Membrane Permeability
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Many candidate drugs with low membrane permeability cannot enter cells effectively, limiting their pharmacological activity despite having strong bioactive properties for treating conditions like tumors, diabetes, and cardiovascular diseases.
Innovation Solution
A compound drug-delivery precursor (X-linker-DNA/RNA) is developed, where X is a compound with no membrane permeability, linked to DNA or RNA using a linker, assisted by gene transfer methods like cationic liposome transfection, to enhance membrane permeation and transfer without damaging cells.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a compound with no membrane permeability is used as a drug, then it cannot penetrate through the cell membrane, but it may have strong bioactivity if it could enter cells
Solution Approach 1:
The patent uses DNA or RNA as an intermediary carrier to transport the compound X across the cell membrane. The compound X is linked to DNA/RNA through a linker group, forming a conjugate that can enter cells via gene transfer methods, thereby enabling the compound to reach its target inside cells without requiring intrinsic membrane permeability
Solution Approach 2:
The patent creates a composite structure consisting of compound X linked to DNA or RNA. This composite molecule combines the bioactive compound with a nucleic acid carrier that has known cell penetration capabilities through transfection methods, thus resolving the membrane permeability issue while preserving the compound's bioactivity
2Object-affected harmful factors
If gene transfer methods are used to transfer the compound into cells, then membrane permeation is improved, but cell damage may occur
Solution Approach 1:
The patent optimizes parameters of the gene transfer method to achieve effective compound delivery while minimizing cell damage. This includes adjusting transfection reagent concentrations, incubation times, and other process parameters to balance delivery efficiency with cell viability
Data Source
Figure 1
Figure 2
Figure 3~4
AI summary
The present invention provides a compound drug-delivery precursor for membrane permeation, and a drug carrier preparation based on this precursor. The compound drug-delivery precursor and the drug carrier preparation of the present invention may effectively improve the membrane permeability of compounds with low membrane permeability and provide a new choice for clinical medication.