Drug Delivery Assembly with Squeezable Dispensing Container

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Solution Overview

Problem

Existing drug delivery devices often suffer from dispensing inaccuracy due to issues like needle dripping after injection, requiring the needle to remain in the skin, which complicates achieving an exact dose of medicinal products.

Innovation Solution

A drug delivery assembly comprising a squeezable dispensing container connected to a reservoir container, with check valves ensuring one-way fluid flow to maintain a defined dose volume and prevent reflow or air intake, utilizing materials like PVC, silicone rubber, or fluoropolymer for chemical resistance, and an actuator to apply force for dispensing.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a conventional drug delivery device with a single container is used, then the device structure is simple, but the dispensing accuracy deteriorates due to needle dripping and difficulty in maintaining exact dose volume

Engineering Contradiction:
Improvedispensing accuracyVSAvoiddevice structure
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system is divided into two separate containers: a reservoir container for bulk storage and a dispensing container for precise dose delivery. This segmentation allows the dispensing container to be designed with a fixed, accurate volume while the reservoir container handles bulk storage, thereby improving dispensing accuracy without requiring the entire device to be overly complex.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

A transfer needle acts as an intermediary between the reservoir container and the dispensing container. It enables controlled fluid transfer from the reservoir to the dispensing container through a check valve mechanism, ensuring unidirectional flow and preventing backflow, which is crucial for maintaining precise dose volume.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Measurement precision

If the needle is kept in the skin after injection to prevent dripping, then the dose accuracy is improved, but the patient comfort and ease of operation deteriorate

Engineering Contradiction:
Improvedose accuracyVSAvoidpatient comfort
Core Design Contradiction:
Measurement precisionVSEase of operation

Solution Approach 1:

The dispensing container is pre-filled with a precise, fixed volume of medicinal product before each use. This preliminary preparation ensures that the exact dose is ready for administration without requiring post-injection needle retention to prevent dripping, as the dose volume is already controlled by the container's fixed capacity.

Inventive Principle:
Principle #10Preliminary action

3Productivity

If a refillable dispensing container is used, then the productivity is improved by reducing waste, but the device complexity increases due to additional connection mechanisms

Engineering Contradiction:
Improveresource utilizationVSAvoidconnection mechanism
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The dispensing container is designed to be refillable from the reservoir container through a simple connection mechanism involving a transfer needle and check valve. The system enables self-service refilling where the excess medicinal product from the reservoir container can be transferred back to the dispensing container after use, reducing waste without requiring complex automated refilling systems.

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This assembly enhances dispensing accuracy by maintaining a consistent dose volume and reducing post-injection needle dripping, ensuring precise and reliable delivery of medicinal products.

Implementation Method 1

check valves ensuring one-way fluid flow to maintain a defined dose volume and prevent reflow or air intake

Methodology Applied
Scientific EffectCheck valve one-way flow control: Valve

Implementation Method 2

the dispensing container is squeezable for dispensing a dose of a fluid medicinal product from the dispensing container

Methodology Applied
Scientific EffectMechanical compression for fluid dispensing: Compression

Implementation Method 3

an actuator to apply force for dispensing

Methodology Applied
Scientific EffectMechanical force application: Mechanical Force

Implementation Method 4

the dispensing container and the reservoir container are connected to one another and are in fluid communication

Methodology Applied
Scientific EffectFluid communication through connecting tube:

Data Source

PatentEP2432523B1Assembly for use in a drug delivery device
Publication Date: 2020.01.15 SANOFI AVENTIS DEUT GMBH
  • EP2432523B1 patent drawingFigure 1
  • EP2432523B1 patent drawing
  • EP2432523B1 patent drawing

AI summary

The present invention relates to an assembly for a drug delivery device comprising a dispensing container (60) and a reservoir container (70) for holding a fluid medicinal product, wherein the dispensing container (60) and the reservoir container (70) are connected to one another and are in fluid communication, and wherein the dispensing container (60) is squeezable for dispensing a dose of the fluid medicinal product from the dispensing container (60), the dispensing container (60) being refillable with the fluid medicinal product from the reservoir container (70).