Automated Drug Desensitization System with Pump Control

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Solution Overview

Problem

Current methods for administering drugs with a high risk of hypersensitivity are manual, prone to errors, and expose personnel to toxic substances, with limitations in accurately controlling injection rates and concentrations, leading to potential hypersensitivity reactions.

Innovation Solution

A system comprising a control device with pumps and valves that automatically dilutes and injects drugs stepwise, minimizing manual intervention and exposure risks, using a mixing unit and catheter connected directly for precise concentration and rate control, with biometric monitoring and real-time flow rate detection.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If manual desensitization therapy is performed according to the 3-bag 12-step protocol, then the therapy can be administered, but nursing personnel are exposed to toxic drugs during dilution and replacement operations

Engineering Contradiction:
Improveexposure to toxic drugsVSAvoidmanual operation complexity
Core Design Contradiction:
Object-affected harmful factorsVSEase of operation

Solution Approach 1:

The patent introduces an automated injection device as an intermediary between the toxic drug and the nursing personnel. The device performs all dilution and injection operations automatically, eliminating direct human contact with the toxic substance while maintaining the ability to execute the complex 12-step protocol.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces manual mechanical operations with an automated pump-based system. The injection pump automatically performs dilution by controlling fluid flow rates and mixing ratios, eliminating the need for manual dilution operations that expose personnel to toxic drugs.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

2Measurement precision

If manual adjustment of pump speed is performed to increase dose at each stage, then the injection rate can be controlled, but the operation is time-consuming and prone to errors

Engineering Contradiction:
Improveinjection rate control precisionVSAvoidtime for manual adjustments
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The automated injection device performs self-adjustment of injection rates through programmed control. The system automatically increases the dose at each stage according to the predetermined 12-step protocol without requiring manual intervention, thereby eliminating time loss and human error while maintaining precise control.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The patent implements automatic parameter changes in the injection rate according to the desensitization protocol. The control system dynamically adjusts pump speed and injection rate parameters at each of the 12 stages, transitioning from manual adjustment to automated parameter modification based on pre-set protocols.

Inventive Principle:
Principle #35Parameter changes

3Loss of information

If manual recording of injection rate changes is performed, then the history can be documented, but the burden on nursing personnel increases

Engineering Contradiction:
Improveinjection rate historyVSAvoidnursing personnel burden
Core Design Contradiction:
Loss of informationVSEase of operation

Solution Approach 1:

The automated injection device incorporates feedback mechanisms that automatically monitor and record injection rate changes at each stage. The system continuously tracks the injection history and stores it in memory, providing automatic documentation without requiring nursing personnel to manually record data, thereby eliminating the burden while preserving complete information.

Inventive Principle:
Principle #23Feedback

4Manufacturing precision

If dilution is performed manually in a 3-bag system, then the protocol can be followed, but the concentration control accuracy is limited due to catheter volume and discharge line characteristics

Engineering Contradiction:
Improveconcentration control accuracyVSAvoiddilution system complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent extracts the dilution function from the traditional 3-bag manual system and integrates it into a single automated injection device. By taking out the dilution operation and performing it internally within the device using precise pump control, the system achieves accurate concentration control while simplifying the overall setup and eliminating the need for multiple bags and manual mixing.

Inventive Principle:
Principle #2Taking out (Extraction)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Automates the desensitization therapy process, reducing hypersensitivity risks by controlling concentration and injection rate, minimizing exposure to toxic drugs, and enhancing convenience through automated operations and real-time monitoring.

Implementation Method 1

a first pump (31) installed on a discharge line connected to the first fluid storage unit (10) so as to control an amount of a first fluid discharged from the first fluid storage unit (10)

Methodology Applied
Scientific EffectPump: Pump

Implementation Method 2

a second pump (32) installed on a discharge line connected to the second fluid storage unit (20) so as to control an amount of a second fluid discharged from the second fluid storage unit (20)

Methodology Applied
Scientific EffectPump: Pump

Implementation Method 3

a mixing unit (40) in which the first fluid discharged from the first fluid storage unit (10) and the second fluid discharged from the second fluid storage unit (20) are mixed

Methodology Applied
Scientific EffectDiffusion: Diffusion

Implementation Method 4

a mixing unit (40) in which the first fluid discharged from the first fluid storage unit (10) and the second fluid discharged from the second fluid storage unit (20) are mixed

Methodology Applied
Scientific EffectConvection: Convection

Data Source

PatentUS20240009381A1Drug hypersensitivity prevention system
Publication Date: 2024.01.11 CEBIKA INC
  • US20240009381A1 patent drawing
  • US20240009381A1 patent drawing
  • US20240009381A1 patent drawing

AI summary

Provided is a drug hypersensitivity prevention system. A drug hypersensitivity prevention system according to an embodiment of the present application may comprise: a first fluid storage unit 10; a second fluid storage unit 20; a control device 30 including a first pump 31 installed in a discharge line connected to the first fluid storage unit 10 so as to control an amount of a first fluid discharged from the first fluid storage unit 10, and a second pump 32 installed in a discharge line connected to the second fluid storage unit 20 so as to control an amount of a second fluid discharged from the second fluid storage unit 20; a mixing unit 40 in which the first fluid discharged from the first fluid storage unit 10 and the second fluid discharged from the second fluid storage unit 20 are mixed; a pouch 50 connected to the mixing unit 40; and a catheter 60 connected to the mixing unit 40.