Drug Dosage Determination Device for Multiple Form Regimens
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Solution Overview
Problem
Healthcare practitioners face challenges in determining optimal administration regimens for drugs available in multiple dosage forms, leading to potential errors and inefficiencies, especially when drugs need to be administered regularly over prolonged periods.
Innovation Solution
A computing device and method that determine the optimal administration regimen by computing all minimal combinations of different dosage forms to achieve the required drug amount, selecting combinations that satisfy multiple criteria, and outputting the optimal regimen for a subject based on their parameters such as weight, age, and disease severity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If healthcare practitioners manually determine administration regimens based on clinical trial conditions and patient parameters, then they can provide personalized treatment, but the complexity of evaluating multiple dosage form combinations leads to errors and inefficiencies
Solution Approach 1:
The patent replaces the manual mechanical process of regimen selection with an automated computing system. The processor executes algorithms that automatically evaluate all possible combinations of dosage forms against clinical trial conditions and patient parameters, eliminating human error and reducing the complexity burden on healthcare practitioners.
Solution Approach 2:
The system enables self-service by allowing the computing device to autonomously determine optimal administration regimens without requiring practitioners to manually evaluate combinations. The device takes patient parameters as input and independently computes the best regimen based on pre-programmed criteria from clinical trials.
2Adaptability or versatility
If all possible combinations of dosage forms are evaluated to find the optimal administration regimen, then the best treatment option is identified, but the computational complexity and time required increase significantly
Solution Approach 1:
The system performs preliminary action by pre-loading clinical trial conditions, dosage form characteristics, and selection criteria into the computing device before patient consultation. This preparation allows the system to quickly evaluate combinations during the actual regimen determination without requiring time-consuming data gathering during the consultation.
Solution Approach 2:
The patent utilizes parameter changes by systematically varying dosage form parameters (amounts, concentrations, combinations) within the computational algorithm. The processor efficiently explores the parameter space by changing dosage form parameters according to predefined rules, enabling comprehensive evaluation without exhaustive brute-force computation.
3Adaptability or versatility
If multiple dosage forms are made available to increase flexibility of administration, then more treatment options exist, but the number of possible administration regimens explodes exponentially
Solution Approach 1:
The computing device serves multiple functions: it stores clinical trial conditions, manages patient parameters, evaluates dosage form combinations, and generates recommended regimens. This multi-functionality consolidates what would otherwise require multiple separate tools or manual processes into a single universal system that handles the complexity of multiple dosage forms.
Solution Approach 2:
The patent introduces an intermediary computational layer between the available dosage forms and the final administration decision. The computing device acts as a mediator that translates the complex relationships between multiple dosage forms and clinical constraints into a manageable set of recommended regimens, reducing the complexity burden on practitioners.
4Reliability
If simple tools are used to calculate drug amount based on patient weight, then calculation errors are reduced, but the tools cannot adequately address the complexity of selecting from multiple dosage forms and administration intervals
Solution Approach 1:
The system transitions from static, simple calculation tools to a dynamic computational platform that can adapt to various patient parameters and dosage form combinations. The computing device dynamically adjusts its evaluation based on input parameters such as patient weight, age, renal function, and the specific characteristics of available dosage forms, providing both accuracy and versatility.
Data Source
AI summary
The application relates to devices and methods for determining an administration regimen of a drug to a subject. Determining an administration regimen for a subject comprises computing the amount of drug to be administered to the subject per elemental period of time, and determining and evaluating combinations of at least two dosage forms that can be used to administered the amount of drug, against at least two different criteria. The methods of the invention find applications in the selection of administration regimen for drugs that are available in multiple dosage forms, and especially drugs that are administered routinely over prolonged periods, such as e.g. in the routine prophylaxis of haemophilia.