Drug Eluting Composite Controlled Release via Segmented Barriers
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current medical devices struggle to control the release rate and duration of therapeutic agents, often leading to unstable or prolonged retention of drugs within the device, which can be undesirable for unstable compositions.
Innovation Solution
The use of combinations of permeable and impermeable compositions and structures within the material allows for controlled release of therapeutic agents by establishing pathways for their exit, with impermeable surfaces acting as barriers and openings facilitating release, enabling tailored delivery profiles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If impermeable compositions and structures are used as barriers within the material, then the release rate of therapeutic agents is controlled and prolonged retention is prevented, but the device complexity increases due to the need for combinations of permeable and impermeable layers with specific pathways
Solution Approach 1:
The material is divided into multiple layers with distinct functions: a first biocompatible polymeric material containing the therapeutic agent, and a second biocompatible polymeric material that is impermeable to the therapeutic agent. This segmentation allows control over drug release while maintaining structural organization.
Solution Approach 2:
The impermeable second polymeric material is applied to cover substantially all of the surface of the first polymeric material, creating localized barrier regions. This local application of impermeability allows controlled release from uncovered areas while preventing release from covered areas, enabling tailored delivery profiles.
2Duration of action of moving object
If pathways are established using combinations of permeable and impermeable compositions, then precise control over release rate and duration is achieved, but the manufacturing precision requirements increase
Solution Approach 1:
The impermeable second polymeric material is applied to the surface of the first polymeric material before the therapeutic agent is fully released. This preliminary action establishes the release pathways and barriers in advance, controlling the subsequent release profile without requiring complex real-time adjustments during manufacturing.
Solution Approach 2:
The invention uses a composite structure combining two different biocompatible polymeric materials with contrasting permeability properties. The first material allows therapeutic agent incorporation and release, while the second material provides impermeable barrier functionality, together creating a composite system with controlled release characteristics.
3Reliability
If impermeable surfaces cover substantially all surfaces of the first polymeric material, then therapeutic agent release is controlled to specific locations, but the surface area available for release is reduced
Solution Approach 1:
The impermeable second polymeric material is applied selectively to cover substantially all of the surface of the first polymeric material, creating localized release zones. This local quality approach ensures reliable targeted delivery from specific areas while minimizing release from other areas, achieving spatial control over drug delivery.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for precise control over the release rate and duration of therapeutic agents, preventing prolonged retention and ensuring effective delivery of drugs, even for unstable compositions, while maintaining biocompatibility and versatility for various medical applications.
Implementation Method 1
compositions and/or structures impermeable to a selected therapeutic agent are also used as barriers to the therapeutic agent on at least portions of one or more surfaces of the invention
Implementation Method 2
a porous biocompatible polymeric material having at least one surface, a therapeutic agent releasably admixed with a biocompatible fluoropolymeric copolymer and incorporated in pores of said porous biocompatible polymeric material
Data Source
AI summary
The present invention relates to materials having therapeutic compositions releasably contained within the materials. The materials are configured to release therapeutic compositions at a desired rate. The present invention also relates to devices incorporating the materials.