Dry Composition for Endoscopy Bowel Cleansing
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Solution Overview
Problem
Current bowel cleansing compositions for endoscopy, particularly in patients with metabolic disorders like diabetes, are inadequate as they induce hypoglycemia, cause discomfort, and lead to suboptimal bowel preparation, increasing the risk of complications and healthcare costs.
Innovation Solution
A dry composition dissolvable in water containing glucose, sugar alcohols, mucoprotectants, amino acids, and anti-nausea substances, designed to maintain osmolarity above 170 mOsm/L, providing a comprehensive solution to support patients during endoscopic procedures by stabilizing blood glucose and reducing discomfort.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If strong laxatives (polyethylene glycol) are used for bowel cleansing, then bowel cleanliness is improved, but patient comfort deteriorates due to nausea and discomfort
Solution Approach 1:
The invention combines multiple substances with different functions into a single composition: polyethylene glycol (laxative effect), sugars (energy supply and osmolarity adjustment), electrolytes (mineral supplementation), and aromatic substances (anti-nausea effect). This composite approach allows simultaneous achievement of bowel cleansing, patient comfort, and metabolic support.
2Manufacturing precision
If prolonged fasting is implemented for bowel preparation, then bowel cleanliness is improved, but patient energy levels deteriorate leading to hypoglycemia
Solution Approach 1:
The composition is administered before the fasting period begins or at the start of bowel preparation. The sugars and electrolytes in the composition provide immediate energy and metabolic support, preventing hypoglycemia during the subsequent fasting period while still achieving bowel cleansing through the laxative effect of polyethylene glycol.
3Manufacturing precision
If split-dose regimen is used for laxative administration, then bowel cleanliness is improved, but treatment complexity increases
Solution Approach 1:
The invention merges multiple functions (laxative, energy supplement, electrolyte replacement, anti-nausea) into a single administered composition. This allows the composition to be taken in one or few doses rather than requiring complex split-dose regimens, simplifying the administration protocol while maintaining effective bowel cleansing.
4Reliability
If hospitalization is implemented for high-risk patients, then patient safety is improved, but healthcare costs increase
Solution Approach 1:
The composition provides beforehand cushioning for high-risk patients by including sugars and electrolytes that prevent hypoglycemia and metabolic disturbances during bowel preparation. This preventive approach allows outpatient administration even for high-risk patients, avoiding hospitalization costs while maintaining patient safety through metabolic protection.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces the risk of hypoglycemia, maintains bowel cleanliness, and alleviates patient anxiety and discomfort during preparation, ensuring standardized glucose levels and optimal bowel cleansing for endoscopic procedures.
Implementation Method 1
aqueous solution of the composition is a clear solution of osmolarity of > 170 mOsm/L
Data Source
AI summary
The subject of invention is a dry composition for dissolving in water containing an osmotic agent, characterised in that it comprises glucose, one or more sugar alcohols and one or more mucoprotectants, for use as supportive product for the organism of a patient preparing for endoscopy, wherein aqueous solution of the composition is a clear solution of osmolarity of > 170 mOsm/L.