Dry Probiotic Composition for Heat-Stable Special Dietary Use
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Solution Overview
Problem
Existing technologies fail to provide stable probiotic compositions that maintain viability under harsh conditions of industrial manufacturing, distribution, and storage, especially at high temperatures and humidity, and are not suitable for special dietary formulations due to regulatory restrictions on conventional stabilizing compounds.
Innovation Solution
A dry probiotic composition comprising viable probiotic microorganisms, hydrolyzed proteins, disaccharides, oligosaccharides, and polysaccharides, prepared through a method involving snap-freezing and vacuum drying to achieve a water activity of 0.3 or lower, ensuring stability and viability under extreme conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional encapsulation and stabilizing compounds are used to protect probiotic viability, then protection against harsh conditions is improved, but regulatory compliance for special dietary formulations deteriorates
Solution Approach 1:
The invention extracts and removes prohibited stabilizing compounds (trehalose, alginate, gum acacia, milk proteins) from the formulation, replacing them with allowed compounds (lactose, sucrose, inulin, maltodextrin, starch, plant proteins) that provide equivalent protective functions while ensuring regulatory compliance for special dietary formulations
Solution Approach 2:
The invention uses composite materials by combining multiple allowed compounds (proteins, disaccharides, oligosaccharides, polysaccharides) to create a stabilization system that achieves the protective效果 of prohibited compounds while maintaining regulatory compliance
2Adaptability or versatility
If probiotics are stored at high temperature and humidity, then distribution and storage flexibility is improved, but probiotic viability deteriorates
Solution Approach 1:
The invention performs preliminary stabilization by incorporating allowed protective compounds (proteins, disaccharides, oligosaccharides, polysaccharides) into the probiotic formulation before storage, creating a protective matrix that preemptively shields probiotics from the damaging effects of high temperature and humidity during distribution and storage
Solution Approach 2:
The invention changes the physical and chemical parameters of the storage environment tolerance by formulating probiotics with stabilization compounds that shift the viability curve, allowing probiotics to maintain acceptable viability levels at higher temperatures and humidity levels that would normally be detrimental
3Stability of the object's composition
If intermediate moisture conditions are maintained, then product stability is improved, but probiotic protection under high temperature deteriorates
Solution Approach 1:
The invention uses composite materials by combining multiple allowed compounds (proteins, disaccharides, oligosaccharides, polysaccharides) to create a stabilization system that achieves the protective效果 of prohibited compounds while maintaining regulatory compliance
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition maintains a viability of at least 1×10^10 CFU/g with less than 1 log unit loss after 1 month at 40°C and 33% RH, suitable for special dietary products like infant formula, overcoming regulatory and environmental challenges.
Implementation Method 1
preparation methods involving snap-freezing and vacuum drying
Implementation Method 2
preparation methods involving snap-freezing and vacuum drying to achieve a water activity of 0.3 or lower
Data Source
AI summary
A dry stable probiotic composition is provided. The composition comprises one or more viable probiotic microorganisms, one or more hydrolyzed proteins, one or more disaccharides, one or more oligosaccharides, and one or more polysaccharides, but not trehalose. The composition has viability of at least 1×1010 CFU/g, and a viability loss of less than 1 log unit/g after one month at a temperature of 40° C. and a relative humidity of 33%. Also provided are methods for preparing the dry stable probiotic composition.