Dry Saline Nasal Rinse Composition With Water-Soluble CBD
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Solution Overview
Problem
There is a need for improved nasal saline compositions that effectively deliver cannabinoids, such as cannabidiol (CBD), to treat chronic rhinosinusitis, allergic rhinitis, and postoperative sinus issues, as existing formulations lack efficacy in clinical studies and do not fully leverage the anti-inflammatory benefits of CBD.
Innovation Solution
A dry composition comprising sodium chloride, sodium bicarbonate, and water-soluble cannabidiol is provided, which can be mixed with water to create isotonic or hypertonic solutions for nasal rinses, allowing for direct intranasal administration of CBD to alleviate symptoms like sinus pain, congestion, and nasal allergies.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If nasal saline irrigation is used to treat chronic rhinosinusitis, then muco-ciliary clearance is improved and intranasal membrane edema is decreased, but the efficacy is insufficient for severe cases and lacks anti-inflammatory benefits
Solution Approach 1:
The patent combines cannabidiol (CBD) with nasal saline to create a composite irrigation solution. The CBD component provides anti-inflammatory and immunomodulatory effects through CB1 and CB2 receptor activation, while the saline component maintains muco-ciliary clearance and hydration. This composite formulation addresses both the insufficiency of standard saline and the need for anti-inflammatory benefits in treating chronic rhinosinusitis.
2Volume of moving object
If high volume nasal saline irrigation is used, then penetration into paranasal sinuses is improved, but the composition does not effectively deliver cannabinoids to target sites
Solution Approach 1:
The patent merges the high volume irrigation mechanism with cannabinoid delivery by formulating CBD into the saline solution. The high volume ensures adequate penetration and distribution throughout the nasal cavity and paranasal sinuses, while the dissolved CBD is simultaneously delivered to target sites. The merging of these two functions into a single formulation resolves the contradiction between volume delivery and active substance delivery.
3Reliability
If cannabinoids are added to nasal saline, then anti-inflammatory effects are achieved, but solubility of cannabinoids in aqueous solution is limited
Solution Approach 1:
The patent addresses the solubility limitation by changing the physical-chemical parameters of the cannabinoid formulation. It specifies using water-soluble cannabidiol or CBD salts (such as CBD hydrochloride), which have enhanced aqueous solubility compared to pure CBD. This parameter change in the molecular form of cannabinoids allows them to dissolve effectively in the aqueous saline base while maintaining their anti-inflammatory pharmacological activity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides effective delivery of CBD through nasal rinses, potentially reducing inflammation and improving symptoms by activating CB1 and CB2 receptors, offering anti-inflammatory and immunomodulatory effects.
Implementation Method 1
CBD has been found to exert anti-inflammatory, analgesic and immunomodulatory effects through activation of receptors cannabinoid-1 (CB1) and cannabinoid-2 (CB2)
Implementation Method 2
A dry composition comprising sodium chloride, sodium bicarbonate, and water-soluble cannabidiol is provided, which can be mixed with water to create isotonic or hypertonic solutions for nasal rinses
Data Source
AI summary
Certain embodiments of the present application relate to a dry composition for preparing a nasal rinse. The dry composition generally includes cannabidiol and a mixture comprising sodium chloride and sodium bicarbonate. In certain forms, the dry composition has less than one percent by weight water. In certain embodiments, the cannabidiol is a water-soluble cannabidiol.