Dry Yeast SAMe Production via Cyclodextrin Stabilization
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Solution Overview
Problem
Current methods for producing S-adenosyl-L-methionine (SAMe) face challenges such as high production costs, thermal instability, and insufficient storage stability, particularly in dry yeast forms, which hinder its economical and widespread use as a therapeutic medication and health food.
Innovation Solution
A method involving the use of a yeast with SAMe production capability, where a cyclodextrin compound is added to a yeast concentrate from a fungus culture liquid, followed by drying, to enhance SAMe concentration and storage stability in dry yeast.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If SAMe is produced by fermentative method using culture medium containing L-methionine, then SAMe can be produced, but production cost is high and storage stability is insufficient
Solution Approach 1:
The patent changes the physical and chemical parameters of SAMe by converting it from free form to salt form (sulfuric acid salt, p-toluenesulfonic acid salt, or butanedisulfonic acid salt), and controls drying parameters to achieve both economical production and improved storage stability
Solution Approach 2:
The patent creates composite material structures by forming SAMe salts with specific acids, which combine the properties of SAMe with the stabilizing effects of the acid salt structures, thereby improving storage stability while maintaining production efficiency
2Reliability
If SAMe is purified by chromatography and formed into salt, then storage stability is improved, but large amounts of labor and cost are required
Solution Approach 1:
The patent performs preliminary action by directly forming SAMe salts during the fermentation and concentration process, before final product preparation, thereby achieving stabilization without requiring separate purification and salt formation steps, reducing both labor and process complexity
3Ease of manufacture
If dry yeast containing SAMe is produced by conventional method, then production is economical, but SAMe cannot have sufficient storage stability
Solution Approach 1:
The patent changes the chemical parameter of SAMe by converting it to salt form and controls the drying process parameters to achieve both economical production through direct processing of culture medium and improved storage stability in the final dry yeast product
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method allows for the production of dry yeast with high SAMe concentration and improved storage stability, enabling efficient and economical production, thereby making SAMe more viable as a therapeutic medication and health food.
Implementation Method 1
a cyclodextrin compound is added to a yeast concentrate obtained from a fungus culture liquid of the yeast, and then the concentrate is dried
Data Source
AI summary
The present invention relates to a method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, the method containing: adding a cyclodextrin compound to a yeast concentrate obtained from a fungus culture liquid of the yeast; and then drying the concentrate, an SAMe-containing dry yeast obtained by the production method, and a composition formed by molding the dry yeast. According to the present invention, a dry yeast containing S-adenosyl-L-methionine, which is useful as an aqueous physiologically active substance, in a high concentration excellent in storage stability and a composition obtained by molding the dry yeast can be produced conveniently and economically and can be brought into the market.