Dual-Cavity Container for Segmented Veterinary Formulations
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Solution Overview
Problem
Current veterinary compositions containing 1-arylpyrazoles and formamidines face challenges with stability and efficacy, particularly in formulations where fipronil and amitraz degrade at physiological pH ranges, leading to short shelf life and inadequate control of fleas and ticks.
Innovation Solution
Formulations combining 1-arylpyrazoles with formamidines in separate carriers, using solvents with specific dielectric constants, and employing dual-cavity containers to maintain stability and enhance synergistic efficacy against ectoparasites.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If 1-arylpyrazoles and formamidines are combined in the same carrier at physiological pH ranges, then synergistic efficacy against parasites is achieved, but stability and shelf life deteriorate due to degradation of fipronil and amitraz
Solution Approach 1:
The formulation is divided into two separate carriers: a first carrier containing the 1-arylpyrazole compound and a second carrier containing the formamidine compound. This segmentation prevents degradation that would occur if both compounds were mixed in the same carrier at physiological pH ranges, while still allowing synergistic efficacy when applied together to the animal.
2Stability of the object's composition
If separate carriers are used for 1-arylpyrazoles and formamidines, then stability is improved, but device complexity increases due to dual-cavity container requirements
Solution Approach 1:
Two separate carriers containing different active ingredients are merged into a single dual-cavity container system. The first carrier with the 1-arylpyrazole compound and the second carrier with the formamidine compound are housed together in one container, maintaining their physical separation for stability while simplifying administration by providing both compounds in a single application unit.
3Device complexity
If conventional single-carrier formulations are used, then device complexity is reduced, but duration of action deteriorates due to rapid degradation of active ingredients
Solution Approach 1:
The formulation is segmented into two separate carriers within a dual-cavity container, preventing degradation that would occur in a single carrier system. This segmentation allows both active ingredients to remain stable and effective for longer periods, extending the duration of protection against fleas and ticks compared to conventional single-carrier formulations.
Data Source
AI summary
Disclosed herein are dual-cavity containers comprising, among other things, a divider wall having a first surface and a second surface opposite the first surface; a first cavity defined by a first wall coupled to the first surface of the divider wall, the first wall having an indenture shaped to conform to a thumb or finger; and a second cavity defined by a second wall and the second surface of the divider wall; the second wall having an indenture shaped to conform to a thumb or finger; and an opening mechanism.