Dual-Channel Sensor Catheter for Stable In Vivo Sensing
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Solution Overview
Problem
Existing in vivo sensing devices face issues such as kinking, folding, and breaking during insertion, and they often lead to stagnant sensor-tissue interfaces, requiring multiple implantation sites which increase trauma and space usage.
Innovation Solution
A sensing and infusion device with flexible, spring-like implantable segments and a dual-channel design that includes a sensor assembly and catheter assembly, allowing for a single implantation site, reducing the likelihood of kinking and stagnant interfaces while enabling both sensing and infusion functions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If sensors are implanted in a subject for prolonged periods, then analyte information can be obtained, but the sensor-tissue interface becomes stagnant
Solution Approach 1:
The sensor is periodically repositioned within the tissue by retracting and re-advancing through the catheter, creating periodic mechanical stimulation that prevents stagnant interface formation while maintaining prolonged implantation capability
2Adaptability or versatility
If multiple implantation sites are used for sensor and catheter, then sensing and infusion functions are achieved, but trauma and space usage increase
Solution Approach 1:
The sensor and catheter are combined into a single integrated assembly that can be inserted through one implantation site, eliminating the need for separate implantation sites and reducing tissue trauma while maintaining both sensing and infusion functions
Solution Approach 2:
The single implantation site serves multiple functions by accommodating both the sensor assembly for analyte detection and the catheter assembly for infusate delivery, making the implantation site universal for both sensing and infusion operations
3Ease of manufacture
If rigid sensor structures are used, then manufacturing is easier, but kinking and breaking occur during insertion
Solution Approach 1:
The sensor is constructed with flexible materials and thin-film structures that allow it to bend and flex during insertion through the catheter without kinking or breaking, while maintaining manufacturing feasibility through established thin-film fabrication techniques
Solution Approach 2:
The sensor structure transitions from a rigid state during manufacturing to a flexible, dynamic state during insertion that can accommodate bending and deformation, then returns to a stable configuration upon deployment in the tissue
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively maintains contact with tissue, reduces trauma, and ensures reliable analyte sensing and infusion by minimizing device breakage and requiring fewer implantation sites.
Implementation Method 1
springs configured to resist kinking, folding, and breaking
Implementation Method 2
pump configured to deliver an infusate through the lumen
Data Source
Figure 1A
Figure 1B
Figure 1C
AI summary
Sensing and infusion devices are described. In one embodiment, a sensing and infusion device may include an implantable segment having a sensor. The sensing and infusion device may also include a catheter, and a sensor channel may be formed in the catheter. The sensor channel may be configured to retain at least a portion of the implantable segment.