Dual-Crosslinked Polymer Film for Durable Implantable Biosensors
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Solution Overview
Problem
Implantable biosensors face issues with damage to the film layer on the working electrode due to external forces and long-term immersion, leading to cracking and peeling, which affects inspection performance and biosafety.
Innovation Solution
A polymer film with a three-dimensional network structure formed by chemically and reversibly physically crosslinked networks, using natural and synthetic high-molecular polymers with covalent and ionic bond crosslinking, enhancing tensile resistance and adhesion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a film layer is placed on the outermost side of the working electrode to control glucose concentration, then the sensing layer can detect higher glucose concentration before saturation, but the film layer easily suffers from damage, cracking, and peeling due to external forces and long-term immersion
Solution Approach 1:
The patent uses a composite polymer film formed by combining natural high-molecular polymer (chitosan) and synthetic high-molecular polymer (polyvinyl alcohol) through dual crosslinking mechanisms. The chemical crosslinking via covalent bonds provides structural stability, while physical crosslinking via ionic bonds with metal ions enhances mechanical flexibility and adhesion. This composite structure resolves the contradiction by maintaining film integrity under external forces while preserving glucose concentration control functionality.
Solution Approach 2:
The patent changes the crosslinking parameters by introducing dual crosslinking modes (chemical and physical) with varying bond strengths. The covalent crosslinking density and ionic crosslinking density are optimized to achieve balanced mechanical properties. This parameter adjustment allows the film to withstand external forces during implantation and long-term immersion while maintaining its glucose diffusion control function.
2Reliability
If the film layer is made more robust to resist damage and cracking, then reliability improves, but the adhesion to the electrode and diffusion control performance may deteriorate
Solution Approach 1:
The patent applies local quality by creating different crosslinking densities in different regions of the polymer network. The chemical crosslinking provides localized structural support for durability, while the physical ionic crosslinking maintains localized flexibility for adhesion. The natural polymer chitosan provides specific local regions with enhanced adhesion properties to the electrode surface, while other regions maintain diffusion control characteristics.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The polymer film improves tensile resistance and adhesion, reducing damage and enhancing the performance and safety of biosensors by providing a stable diffusion-limiting layer.
Implementation Method 1
The chemically crosslinked network has covalent bond crosslinking between the synthetic high-molecular polymers and covalent bond crosslinking between the natural high-molecular polymer and the synthetic high-molecular polymer
Implementation Method 2
The physically crosslinked network has ionic bond crosslinking between the natural high-molecular polymers. In the physically crosslinked network, metal ions are dynamic crosslinking points
Implementation Method 3
Both the natural high-molecular polymer and the synthetic high-molecular polymer are hydrophilic polymers
Data Source
AI summary
Some embodiments of the disclosure provide a polymer film used for a biosensor. The polymer film has a three-dimensional network structure formed by a natural high-molecular polymer and a synthetic high-molecular polymer by a plurality of crosslinking modes. The three-dimensional network structure includes a chemically crosslinked network and a reversible physically crosslinked network, the chemically crosslinked network being formed by covalent bond crosslinking and the reversible physically crosslinked network being formed by ionic bond crosslinking. The chemically crosslinked network has covalent bond crosslinking between the synthetic high-molecular polymers and covalent bond crosslinking between the natural high-molecular polymer and the synthetic high-molecular polymer. The physically crosslinked network has ionic bond crosslinking between natural high-molecular polymers.