Dual Detector Tissue Chemical Analysis
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Solution Overview
Problem
Current methods for detecting skin cancer, such as malignant melanoma, are often invasive, inaccurate, and require skilled personnel, with high uncertainty and risk of infection, while non-invasive methods like image analysis are limited in sensitivity and specificity.
Innovation Solution
A non-invasive chemical detector system using two identical detectors positioned on suspected and healthy tissue areas to detect changes in metabolite emissions through differences in electrical, optical, or chemical properties, with adsorbent materials like metals or polymers to identify specific substances like hydrogen peroxide or Dimethyl Disulfide.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If visual inspection and microscope examination are used to detect skin cancer, then detection capability is improved, but the method becomes invasive, requires skilled personnel, and has high uncertainty
Solution Approach 1:
The patent replaces the mechanical/visual inspection system with a chemical detection system that measures metabolite emissions. Instead of using microscopes and skilled personnel to visually examine tissue samples, the invention uses chemical sensors to detect and quantify specific metabolites (such as hydrogen peroxide, dimethyl disulfide) emitted by cancerous cells, thereby eliminating the need for complex sample preparation and expert visual assessment while maintaining high detection accuracy
Solution Approach 2:
The patent introduces metabolites as intermediary substances that mediate between the cancerous tissue and the detection system. Rather than directly observing or sampling tissue cells, the detection system measures the chemical substances emitted by metabolically active cancer cells. These metabolites serve as indirect indicators of malignancy, simplifying the detection process while preserving diagnostic accuracy
2Measurement precision
If invasive sample extraction is performed to detect malign cells, then detection precision is improved, but the risk of infection and patient discomfort increases
Solution Approach 1:
The patent uses metabolite emissions as intermediary markers that can be detected without breaking the skin or extracting tissue samples. Cancerous cells emit characteristic chemical substances (metabolites) that serve as indirect indicators of malignancy, allowing detection to proceed without invasive procedures, thereby eliminating infection risks while maintaining diagnostic precision
Solution Approach 2:
The patent replaces the mechanical extraction of tissue samples with a non-invasive chemical measurement system. Instead of physically removing and examining tissue under a microscope, the system uses chemical sensors to detect and quantify metabolites in the vicinity of the suspected lesion, eliminating the need for incisions, sample handling, and laboratory processing that carry infection risks
3Object-affected harmful factors
If image analysis methods are used for non-invasive detection, then patient safety is improved, but sensitivity and specificity are reduced
Solution Approach 1:
The patent changes the detection parameter from optical/visual properties (used in image analysis) to chemical properties (metabolite emissions). While image analysis measures light reflection, absorption, or scattering from tissue surfaces, this invention measures the concentration and composition of chemical substances emitted by metabolically active cancer cells. This parameter change enables non-invasive detection while achieving superior sensitivity and specificity, as metabolite profiles provide direct information about cellular metabolic state rather than indirect visual characteristics
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables early and cost-efficient detection of skin cancer, reducing the risk of tumor metastasis and improving survival rates by enhancing the ability to detect changes in tissue properties with high sensitivity and specificity.
Implementation Method 1
detect changes in tissue, such as skin cancer, such as malignant melanoma, basal cell carcinoma, or squamous cell carcinoma, by a non-invasive method based on chemical detection and chemical reaction of emission of evaporating metabolites emanating from skin
Implementation Method 2
with adsorbent materials like metals or polymers to identify specific substances like hydrogen peroxide or Dimethyl Disulfide
Data Source
AI summary
The present disclosure relates to a device and method for detecting chemicals from tissue, such as skin, comprising at least a first detector (A) and at least a second detector (B), wherein the first detector (A) and the second detector (B) are the same type of detectors. An attachment portion (C3) including at least the first detector (A) and at least the second detector (B) separated by a defined distance, the attachment portion is configured to be attached on the tissue for detection of the chemicals.