Automated Sample Processing System for Dual-Format HPV Testing
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Solution Overview
Problem
Current automated and semi-automated sample processing systems are labor-intensive, prone to operator errors, and often require cumbersome pre-processing steps, lacking safety controls and efficiency, especially when handling samples in various formats.
Innovation Solution
An automated sample processing system capable of receiving and processing samples in different formats, featuring a dual-input system for pre-processed and unprocessed cervical samples, with integrated subsystems for preparing and testing specimens for human papillomavirus indicators, and a central control unit for coordinating operations, enabling high-throughput and reliable processing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If manual or semi-automated processing methods are used, then flexibility in handling various sample formats is maintained, but labor intensity increases and operator errors occur
Solution Approach 1:
The system employs a universal sample interface that can accept multiple sample formats (microplate wells, tubes, racks) through a single processing system. The sample holder mechanism is designed to accommodate different container types and configurations, allowing one system to perform multiple functions across various sample formats without requiring separate processing lines for each sample type.
Solution Approach 2:
An intermediary sample holder and transfer mechanism serves as a mediator between the diverse sample input formats and the standardized processing interior of the system. This intermediary component translates various sample container types into a unified processing interface, enabling the system to handle different sample formats through a common automated processing pathway.
2Productivity
If automated systems are used to reduce labor costs, then productivity increases, but device complexity and requirement for pre-processing steps increase
Solution Approach 1:
The automated processing system is segmented into distinct functional modules: sample loading mechanism, sample transfer system, processing chamber, and result output. Each module performs a specific function and can operate independently, reducing overall system complexity while maintaining high throughput. The segmentation allows for modular design where each component is optimized for its specific task without requiring the entire system to be complex.
Solution Approach 2:
The system incorporates self-service features where the automated mechanism automatically loads samples, positions them in the processing chamber, and executes the testing protocol without requiring manual intervention. The system manages its own operation flow, reducing the need for complex external control systems and minimizing the operational complexity burden on users.
3Reliability
If existing automated systems are used, then operator errors are reduced, but safety controls are insufficient and service interruptions occur
Solution Approach 1:
The system incorporates feedback mechanisms that continuously monitor processing conditions, sample integrity, and system status. Sensors detect anomalies such as improper sample loading, reagent depletion, or processing deviations and automatically trigger corrective actions or halt operation to prevent errors. This feedback loop ensures high reliability while maintaining safety by preventing harmful conditions from developing.
Solution Approach 2:
The system includes beforehand cushioning features such as safety interlocks, automated sample containment mechanisms, and pre-check protocols that prevent harmful events before they occur. The system is designed with built-in safety margins that cushion against potential failures, such as automated containment of biohazardous samples and pre-validation of processing parameters to prevent erroneous operations.
4Manufacturing precision
If samples must be transferred to specific containers for automated processing, then processing consistency is improved, but loss of time for pre-processing steps occurs
Solution Approach 1:
The system performs preliminary action by automatically preparing and positioning samples in the correct processing configuration as part of the automated workflow. Samples are pre-positioned in the sample holder mechanism during the loading phase, and the system automatically executes the complete processing protocol including reagent addition and measurement, eliminating the need for separate pre-processing steps while maintaining processing consistency.
Solution Approach 2:
The system merges the sample transfer, positioning, and processing initiation into a single integrated automated operation. Instead of separate steps for container transfer and processing preparation, the system combines these functions into one coordinated action where samples are directly transferred to the processing chamber in the correct configuration, eliminating time loss while maintaining precision.
Data Source
AI summary
The present disclosure provides an automated sample processing system that can receive samples in different first and second formats and process both sample formats. The disclosure also provides a human papillomavirus testing apparatus. The apparatus has a first input to receive first test specimens in the form of pre-processed cervical samples, and a second input to receive unprocessed cervical samples. A first subsystem prepares second test specimens from the unprocessed cervical samples, and a second subsystem selectively processes and tests first specimens, second test specimens, or first and second test specimens to determine the presence of one or more human papillomavirus indicators.