Dual-Frequency Light Modulation for Analyte Measurement Fault Detection
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Solution Overview
Problem
Existing methods for determining analyte concentrations in body fluids using photometric measurements face challenges such as interference from internal and external disturbances, leading to faulty measurements and waste of test carriers, especially with the increasing use of modern light sources and miniaturization of devices.
Innovation Solution
The method involves using a light source modulated at two different frequencies to illuminate a test carrier, with a detector receiving and demodulating the remitted light to generate demodulated signals, allowing for real-time fault detection and reduction of measurement errors, thereby ensuring accurate analyte concentration determination without discarding test carriers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If photometric measurements are performed using conventional light sources, then analyte concentration can be determined, but measurement reliability deteriorates due to interference from internal and external disturbances
Solution Approach 1:
The light source is modulated at two different frequencies to create periodic illumination patterns. This periodic action allows the measurement system to distinguish between signals caused by the light source and those caused by ambient disturbances, thereby improving measurement reliability while reducing the impact of harmful interference factors
Solution Approach 2:
The system changes the operational parameters of the light source by modulating it at two distinct frequencies. This parameter change enables the detection system to separate the analyte signal from background noise and disturbances through frequency discrimination, thus improving reliability without being affected by conventional interference
2Loss of information
If fault detection is performed after measurement completion, then measurement errors can be identified, but test carriers are wasted due to faulty measurements going undetected
Solution Approach 1:
The system performs preliminary fault detection during the measurement process itself by analyzing the modulated light signals in real-time. This preliminary action allows identification of measurement faults before the measurement is completed, preventing waste of test carriers while maintaining measurement precision through continuous monitoring
3Measurement precision
If single frequency modulation is used, then device complexity is reduced, but measurement precision deteriorates due to inability to distinguish signals from disturbances
Solution Approach 1:
The light source is modulated at two different frequencies to create periodic illumination patterns. This periodic action allows the measurement system to distinguish between signals caused by the light source and those caused by ambient disturbances, thereby improving measurement reliability while reducing the impact of harmful interference factors
Solution Approach 2:
The system changes the operational parameters of the light source by modulating it at two distinct frequencies. This parameter change enables the detection system to separate the analyte signal from background noise and disturbances through frequency discrimination, thus improving reliability without being affected by conventional interference
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables reliable determination of analyte concentrations in body fluids even in the presence of disturbances, reducing the need for repeated samples and test carriers by identifying and correcting faults during the measurement process.
Implementation Method 1
a light source modulated at two different frequencies
Implementation Method 2
a detector receiving and demodulating the remitted light
Implementation Method 3
reflective measurements are performed to determine an amount of light elastically or inelastically reflected, scattered, or remitted by the test carrier
Data Source
AI summary
Methods, analytical devices and analytical systems are provided for determining at least one analyte concentration in a body fluid sample. The methods, which may be incorporated into the devices and systems, can include the following steps: applying a body fluid to a test carrier; illuminating the test carrier by at least one light source, where the at least one light source is modulated by using at least two modulation frequencies; receiving light remitted by the test carrier by using at least one detector; determining an analyte concentration by evaluating at least one detector signal generated by the detector, where the detector signal is demodulated with the at least two modulation frequencies to generate at least two demodulated detector signals, each demodulated signal corresponding to one of the modulation frequencies; and detecting a fault by comparing the at least two demodulated detector signals.