Dual-Layer Intrasaccular Mesh for Wide-Neck Aneurysm Occlusion
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Solution Overview
Problem
Current treatments for cerebral aneurysms, such as stents and vaso-occlusive coils, face challenges including limited effectiveness in wide-necked aneurysms, risk of migration, and difficulty in positioning defect spanning portions due to lack of rotational flexibility and poor flexibility in navigating tortuous cerebral blood vessels.
Innovation Solution
Development of an intrasaccular occlusive device with a dual-layer permeable shell made of woven filaments, where the outer layer is softer than the inner layer, allowing for controlled deployment and anchoring within the aneurysm to block blood flow, reduce deformation risk, and promote thrombosis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If current stents and vaso-occlusive coils are used to treat cerebral aneurysms, then blood flow can be blocked, but the devices lack rotational flexibility and flexibility in navigating tortuous cerebral blood vessels
Solution Approach 1:
The device is divided into multiple segments including a flexible delivery catheter and a modular occlusive device that can be navigated through tortuous vessels and then deployed to block blood flow. The segmented structure allows the device to conform to vessel curvature while maintaining occlusion capability.
Solution Approach 2:
The occlusive device incorporates flexible membranes and thin-walled structures that can navigate tortuous cerebral blood vessels. These flexible components allow the device to bend and conform to vessel geometry while maintaining structural integrity for effective blood flow occlusion when deployed.
2Reliability
If current treatments are used for wide-necked aneurysms, then some occlusion can be achieved, but the devices have limited effectiveness and high risk of migration
Solution Approach 1:
The occlusive device is delivered nested within a delivery catheter system that provides support and positioning. The nested structure allows the device to be precisely positioned in wide-necked aneurysms and prevents migration during deployment, while the expanded occlusive portion provides reliable blood flow blockage.
Solution Approach 2:
The delivery catheter acts as an intermediary that facilitates safe delivery and positioning of the occlusive device in wide-necked aneurysms. The catheter provides mechanical support during navigation and deployment, reducing the risk of device migration and deformation while enabling effective occlusion.
3Productivity
If surgical techniques with clips are used to treat cerebral aneurysms, then immediate occlusion can be achieved, but the procedures require major invasive surgery with extended periods under anesthesia
Solution Approach 1:
The invention replaces the mechanical surgical clipping system with a percutaneous catheter-based delivery system. The occlusive device is delivered through a catheter and deployed endovascularly, eliminating the need for craniotomy and direct surgical manipulation while achieving comparable occlusion results with minimal invasiveness.
Solution Approach 2:
The delivery catheter serves as an intermediary that enables the occlusive device to reach the aneurysm site through the vascular system without requiring open surgery. This intermediary approach allows immediate occlusion to be achieved through minimally invasive percutaneous access rather than major surgical intervention.
4Ease of operation
If uncovered stents with reduced density are used to fit through microcatheters, then delivery is enabled, but the stents do not block enough flow to cause clotting
Solution Approach 1:
The device is segmented into a delivery catheter portion and an occlusive device portion. The occlusive device is collapsed within the catheter for delivery through microcatheters, then expanded at the target site to provide sufficient flow blocking. This segmentation allows the device to meet both deliverability and occlusion effectiveness requirements.
Solution Approach 2:
The occlusive device transitions from a compressed static state during delivery through the microcatheter to an expanded dynamic state at the treatment site. This dynamic transformation allows the device to fit through small catheters while providing adequate flow occlusion when deployed, overcoming the limitation of reduced-density stents.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively occludes blood flow into cerebral aneurysms, minimizing the risk of rupture and deformation, while allowing initial perfusion to facilitate healing and providing immediate feedback on treatment success.
Implementation Method 1
a permeable shell made of a woven filament structure
Implementation Method 2
the outer layer is softer than the inner layer, allowing for controlled deployment and anchoring within the aneurysm to block blood flow, reduce deformation risk
Data Source
AI summary
Devices and methods for treatment of a patient's vasculature are described. Embodiments may include a first permeable shell and a second permeable shell, where the second permeable shell sits within an interior cavity of the first permeable shell. The first and second permeable shells may each be made from a plurality of elongate filaments that are woven together to form a mesh. The mesh of the first permeable shell may have a larger mesh density and be softer than the mesh of the second permeable shell.