Dual-Layer Cannabinoid Chewing Gum for Fast and Sustained Release
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Solution Overview
Problem
Existing cannabinoid delivery systems face challenges such as low solubility, stability, erratic absorption, and variable bioavailability due to their lipophilic nature, leading to inefficient oral mucosal delivery and adverse effects, while current chewing gum formulations suffer from complex production, limited control over drug release, and variable absorption.
Innovation Solution
A medicinal chewing gum with an inner core containing lipophilic nanosized cannabinoids and an outer layer with hydrophilic nanosized cannabinoids, utilizing a PIB-PEO gum base and synergistic compounds like Boswellia sp. extract, provides controlled and quick release profiles for improved pharmacokinetic and pharmacodynamic effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cannabinoids are administered orally, then systemic delivery is achieved, but first-pass metabolism and gastric acidity cause low bioavailability and erratic absorption
Solution Approach 1:
The chewing gum is designed with a dual-layer structure: an inner core containing lipophilic nanosized cannabinoids for sustained release and an outer layer containing hydrophilic nanosized cannabinoids for rapid release. This segmentation allows simultaneous achievement of fast onset and reliable bioavailability by distributing different cannabinoid formulations across different temporal phases of absorption.
Solution Approach 2:
The patent uses nanosized formulations as intermediaries to bridge the gap between oral administration and effective absorption. The nanosized cannabinoids in both hydrophilic and lipophilic forms serve as mediators that enhance solubility, stability, and absorption efficiency, thereby improving bioavailability while maintaining rapid onset.
2Reliability
If cannabinoids are made more soluble through formulation, then bioavailability improves, but chemical stability decreases due to solution form
Solution Approach 1:
The patent changes the physical state parameter of cannabinoids from bulk form to nanosized form, and controls the solubility parameter by providing both hydrophilic and lipophilic versions. This allows the cannabinoids to maintain chemical stability while achieving improved solubility and bioavailability through the nanoscale dimension and controlled release mechanisms.
Solution Approach 2:
The chewing gum combines hydrophilic and lipophilic nanosized cannabinoids within a composite gum base matrix. This composite structure provides both solubility enhancement and chemical stability, as the gum base protects the nanosized cannabinoids from degradation while allowing controlled release, thus resolving the contradiction between stability and solubility.
3Ease of manufacture
If chewing gum formulation is simplified, then manufacturing ease improves, but control over drug release becomes limited
Solution Approach 1:
The dual-layer structure with inner core and outer layer provides segmented release control: the outer layer releases cannabinoids rapidly for immediate relief, while the inner core provides sustained release. This segmentation achieves precise control over drug release timing and duration while maintaining a relatively simple chewing gum formulation that can be manufactured using standard extrusion techniques.
4Reliability
If lipophilic cannabinoids are used, then absorption efficiency improves, but solubility in aqueous environments decreases
Solution Approach 1:
The patent changes the solubility parameter by providing both hydrophilic and lipophilic nanosized cannabinoids. The lipophilic version maintains high absorption efficiency through membrane permeability, while the hydrophilic version ensures adequate solubility in aqueous environments. The nanosization process itself also enhances both parameters by increasing surface area and reducing particle size effects.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The gum achieves rapid symptom relief and long-lasting effects by ensuring efficient absorption and stability of cannabinoids, enhancing bioavailability and reducing adverse effects through controlled release mechanisms.
Implementation Method 1
provides controlled and quick release profiles for improved pharmacokinetic and pharmacodynamic effects
Implementation Method 2
ensuring efficient absorption and stability of cannabinoids, enhancing bioavailability
Data Source
AI summary
A medicinal chewing gum has an inner core containing a first gum base and a first cannabinoid in a lipophilic nanosized form and an outer layer containing a second gum base and a second cannabinoid in a hydrophilic nanosized form, thereby providing quick release of the second cannabinoid in the outer layer and sustained release of the first cannabinoid in the inner layer. At least one of the inner core and the outer layer contains a synergistic compound having a synergistic effect with at least one of the first and second cannabinoids in the treatment of a medical condition. At least one of the first cannabinoid and the second cannabinoid are a cannabinoid other than cannabidiol (CBD).