Medicinal Dual-Layer Chewing Gum for Rapid and Sustained Cannabinoid Release

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Solution Overview

Problem

Existing cannabinoid delivery systems face challenges such as low solubility, stability, erratic absorption, and variable bioavailability due to their lipophilic nature, leading to ineffective treatment of medical conditions like pain and inflammation.

Innovation Solution

A medicinal chewing gum with a dual-layer structure, containing a lipophilic inner core and a hydrophilic outer layer, where cannabinoids are in nanosized forms, providing quick and sustained release, and incorporating synergistic compounds like Boswellia sp. extracts to enhance absorption and stability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If cannabinoids are administered orally, then systemic delivery is achieved, but bioavailability is low and absorption is erratic due to first-pass metabolism and gastric acidity

Engineering Contradiction:

ImprovebioavailabilityVSAvoidonset time

Core Design Contradiction:

ReliabilityVSLoss of time

Solution Approach 1:

The chewing gum is divided into two distinct layers: an inner core layer containing lipophilic cannabinoids and an outer layer containing hydrophilic cannabinoids. This segmentation allows different cannabinoid types to be released at different rates, with the outer layer providing rapid onset and the inner core providing sustained release, thereby improving both bioavailability and onset time characteristics

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Different regions of the chewing gum are designed with different properties: the outer layer has hydrophilic characteristics for rapid dissolution and quick absorption, while the inner core has lipophilic characteristics for sustained release. This local differentiation optimizes both fast onset and reliable bioavailability across different parts of the dosage form

Inventive Principle:

Principle #3Local quality

2Quantity of substance

If cannabinoids are formulated in non-aqueous solutions, then solubility is improved, but stability deteriorates due to chemical degradation via light, temperature, and auto-oxidation

Engineering Contradiction:

ImprovesolubilityVSAvoidchemical stability

Core Design Contradiction:

Quantity of substanceVSStability of the object's composition

Solution Approach 1:

The chewing gum combines hydrophilic and lipophilic materials in a composite structure. The outer layer uses hydrophilic polymers that provide stability and protect against degradation, while the inner core uses lipophilic materials that maintain cannabinoid solubility. This composite approach simultaneously achieves both stability and solubility

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The gum base acts as an intermediary carrier that bridges the contradiction between hydrophilic and lipophilic requirements. It provides a matrix that can incorporate both water-soluble and fat-soluble cannabinoids, protecting them from degradation while maintaining their solubility characteristics

Inventive Principle:

Principle #24Intermediary (Mediator)

3Ease of manufacture

If a single-layer chewing gum is used, then manufacturing is simple, but release profile is erratic and cannot provide both quick and sustained release

Engineering Contradiction:

Improvemanufacturing complexityVSAvoidrelease profile

Core Design Contradiction:

Ease of manufactureVSDuration of action of moving object

Solution Approach 1:

The chewing gum is segmented into two functional layers with distinct release characteristics. The outer layer provides quick release for immediate symptom relief, while the inner core provides sustained release for long-lasting effects. This segmentation enables control over the release profile while maintaining reasonable manufacturing simplicity through sequential layer formation

Inventive Principle:

Principle #1Segmentation

4Reliability

If lipophilic cannabinoids are used, then membrane permeability is improved, but solubility in aqueous environments deteriorates

Engineering Contradiction:

Improvemembrane permeabilityVSAvoidaqueous solubility

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The chewing gum creates local quality differentiation where the inner core maintains lipophilic characteristics for membrane permeability, while the outer layer provides hydrophilic characteristics for aqueous solubility and stability. This allows the formulation to simultaneously achieve both membrane permeability and aqueous solubility in different regions

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The dual-layer chewing gum improves pharmacokinetic and pharmacodynamic profiles, ensuring rapid symptom relief and long-lasting effects for conditions like pain and inflammation by optimizing cannabinoid release and bioavailability.

Implementation Method 1

an inner core containing a first gum base and a first cannabinoid in a lipophilic nanosized form

Methodology Applied

Scientific EffectLipophilic diffusion: Diffusion

Implementation Method 2

an outer layer containing a second gum base and a second cannabinoid in a hydrophilic nanosized form

Methodology Applied

Scientific EffectHydrophilic dissolution: Solvation

Implementation Method 3

providing quick release of the second cannabinoid in the outer layer and sustained release of the first cannabinoid in the inner layer

Methodology Applied

Scientific EffectControlled release:

Data Source

PatentUS12383591B2Chewing gum containing synergistic medicinal compounds

Publication Date: 2025.08.12 LONDON PHARMA & RES CORP

AI summary

A medicinal chewing gum has an inner core containing a first gum base and a first cannabinoid in a lipophilic nanosized form and an outer layer containing a second gum base and a second cannabinoid in a hydrophilic nanosized form, thereby providing quick release of the second cannabinoid in the outer layer and sustained release of the first cannabinoid in the inner layer. At least one of the inner core and the outer layer contains a synergistic compound having a synergistic effect with at least one of the first and second cannabinoids in the treatment of a medical condition.