Porous Chromatographic Media with Dual Macropores for Cannabinoid Purity
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Solution Overview
Problem
There is an ongoing need for novel chromatographic matrices capable of facilitating the separation and purification of compounds, particularly for applications such as affinity and reverse phase chromatography, with improved efficiency and selectivity.
Innovation Solution
The development of tailored chromatographic media (TCM) comprising porous resins or carbons with specific pore structures and surface areas, combined with anionic polysaccharides, to enhance separation and purification processes, particularly for cannabinoids from cannabis plants, achieving high purity levels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional chromatographic media are used, then basic separation is achieved, but separation efficiency and selectivity are insufficient
Solution Approach 1:
The patent employs porous resins and carbons with specifically engineered pore structures (micropores, mesopores, and macropores) to enhance separation efficiency. The porous architecture provides increased surface area and optimized mass transfer pathways, allowing compounds to be separated more effectively while maintaining high selectivity through controlled pore size distributions.
Solution Approach 2:
The chromatographic media combines multiple materials with complementary properties: porous resins or carbons provide the structural framework and surface area, anionic polysaccharides contribute functional groups for selective interactions, and the composite structure enables both high separation efficiency and reliability through synergistic effects of its components.
2Manufacturing precision
If chromatographic separation is performed on cannabis extracts, then cannabinoid purification is achieved, but achieving high purity levels exceeds current capabilities
Solution Approach 1:
The chromatographic media features localized functional properties through the strategic distribution of anionic polysaccharides and functional moieties within the porous structure. This local quality enhancement creates specific interaction zones that selectively bind target cannabinoids, enabling purification to exceed 90% purity while maintaining productive separation rates.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The TCM achieves high purity separations of cannabinoids exceeding 90%, with tailored pore distributions and functional moieties enhancing separation efficiency and selectivity.
Implementation Method 1
Separation is based on partitioning of the mixture between the mobile and stationary phase. The forces that govern partitioning range vary (e.g., size, charge)
Implementation Method 2
wherein the tailored chromatographic media further comprises an anionic polysaccharide and a functional moiety
Data Source
AI summary
Tailored chromatographic media and methods for using the tailored chromatographic media to purify mixtures extracted from cannabis to obtain a cannabinoid having greater than about 90% purity. In an embodiment, the tailored chromatographic media may comprise a porous resin and/or porous carbon and have a surface area of greater than about 900 m2/g, wherein the tailored chromatographic media may further comprise micropores, mesopores, macropores, wherein the tailored chromatographic media may further comprise at least two distributions of macroporous pore sizes, wherein the at least two distributions of macroporous pore sizes may comprise a first population having a macroporous pore size denoted x and a second population having a macroporous pore size denoted y, wherein a ratio of x/y may be about 1:1, and wherein the tailored chromatographic media may further comprise an anionic polysaccharide and a functional moiety.