Dual-Mode Probe for Hydrogen Sulfide Detection
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Solution Overview
Problem
Current methods for detecting hydrogen sulfide in the body, particularly in the brain, are invasive, limited by optical imaging penetration, and fail to accurately quantify H2S concentrations non-invasively, hindering research on its physiological and pathological roles.
Innovation Solution
A dual-modality probe combining a radioisotope copper ligand with a fluorescent substance, forming a complex that enables both fluorescence and nuclear imaging, allowing for selective imaging of hydrogen sulfide with high blood-brain barrier permeability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If fluorescent probes are used to detect hydrogen sulfide, then detection sensitivity is improved, but imaging penetration depth is limited
Solution Approach 1:
The patent combines a fluorescent probe with a radioisotope (64Cu) to create a dual-modality probe that can be detected by both fluorescence imaging and nuclear medicine imaging. This merging allows the probe to maintain high detection sensitivity while achieving deep tissue penetration through nuclear imaging capabilities, resolving the contradiction between sensitivity and penetration depth.
Solution Approach 2:
The probe is designed to serve multiple imaging functions simultaneously - it acts as both a fluorescent probe for high-resolution cellular imaging and a nuclear medicine tracer for deep tissue imaging. This multi-functionality allows the same probe to address both the sensitivity requirements of fluorescence imaging and the penetration requirements of nuclear imaging.
2Measurement precision
If invasive methods are used to detect hydrogen sulfide, then measurement accuracy is improved, but biological imaging capability is lost
Solution Approach 1:
The patent replaces invasive mechanical detection methods with non-invasive optical and nuclear imaging techniques. The dual-modality probe enables accurate H2S measurement through fluorescence and nuclear imaging without requiring tissue biopsy or invasive sampling, thus maintaining measurement accuracy while enabling non-invasive biological imaging.
Solution Approach 2:
The probe acts as an intermediary that translates invisible H2S molecules into detectable signals for both fluorescence and nuclear imaging. This intermediary function allows accurate H2S detection without direct invasive contact with the target tissue, maintaining measurement precision while enabling non-invasive imaging.
3Measurement precision
If optical imaging is used to image the brain, then cellular resolution is improved, but tissue penetration is limited
Solution Approach 1:
The patent merges fluorescence imaging capability with nuclear medicine imaging capability into a single dual-modality probe. This combination allows simultaneous achievement of high cellular resolution through fluorescence imaging and deep tissue penetration through nuclear imaging, specifically enabling brain imaging that was previously inaccessible to optical methods alone.
Solution Approach 2:
The patent adds a new dimension to imaging by incorporating nuclear medicine capabilities alongside optical imaging. This dimensional expansion allows the system to overcome the penetration limitations of pure optical imaging while maintaining the resolution benefits, effectively adding a deep-tissue imaging dimension to the existing optical imaging approach.
Data Source
AI summary
The present invention relates to a dual-mode probe for detecting of hydrogen sulfide and use thereof and, more specifically to a dual-mode probe that has excellent blood-brain barrier permeability and is capable of fluorescence and nuclear imaging and a use thereof for detecting hydrogen sulfide.