Dual-Mode Insulin Delivery Settings From Closed-Loop Data

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Solution Overview

Problem

Existing insulin infusion devices lack the ability to optimize therapy settings based on patient-specific data collected during closed-loop operation, leading to suboptimal insulin delivery and glycemic control.

Innovation Solution

A system that analyzes data from a dual-mode insulin infusion device operating in closed-loop mode to determine updated settings for manual mode, adjusting parameters such as basal rate and insulin sensitivity factor, using cloud-based computing to generate and implement recommendations for improved insulin delivery.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If the infusion device operates in manual mode with fixed settings, then the device complexity is reduced and ease of operation is improved, but the glycemic control precision deteriorates

Engineering Contradiction:
Improveease of operationVSAvoidglycemic control precision
Core Design Contradiction:
Ease of operationVSMeasurement precision

Solution Approach 1:

The patent implements dynamic adjustment of infusion device settings by analyzing closed-loop operation data and automatically updating parameters such as basal rate and insulin sensitivity factor. The system transitions from static fixed settings to dynamic adaptive settings that evolve based on patient response patterns, thereby improving glycemic control precision while maintaining ease of use through automated optimization.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent employs feedback mechanisms where glucose sensor data and insulin delivery data from closed-loop operation are collected, analyzed, and used to generate recommendations for setting adjustments. This closed feedback loop allows the system to continuously learn from patient responses and refine manual mode settings, resolving the contradiction between operational simplicity and control precision.

Inventive Principle:
Principle #23Feedback

2Measurement precision

If the device collects and analyzes closed-loop data to optimize manual mode settings, then the glycemic control precision is improved, but the device complexity increases

Engineering Contradiction:
Improveglycemic control precisionVSAvoiddevice complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent segments the optimization process into distinct functional modules: data collection from closed-loop operation, data analysis to identify patterns, generation of setting adjustment recommendations, and implementation of updated parameters. This modular segmentation allows complex optimization functionality to be managed through organized, independent components, reducing overall system complexity while maintaining high precision.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The system performs self-optimization by automatically analyzing its own closed-loop operation data and generating recommendations for improving its manual mode performance. This self-service capability eliminates the need for external manual tuning, reducing the operational complexity burden on users while achieving precise glycemic control through automated learning and adaptation.

Inventive Principle:
Principle #25Self-service

3Adaptability or versatility

If separate parameter values are maintained for manual and closed-loop modes, then the adaptability is improved, but the device complexity increases

Engineering Contradiction:
ImproveadaptabilityVSAvoiddevice complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The patent applies local quality by maintaining distinct parameter sets tailored to specific operational modes (manual vs. closed-loop). Each mode has its own optimized parameters such as basal rate and insulin sensitivity factor, allowing the system to adapt settings locally to the specific requirements of each mode while using a unified overall architecture that manages complexity through organized parameter management.

Inventive Principle:
Principle #3Local quality

Data Source

PatentUS20250319254A1Determination of adjustments to fluid delivery settings
Publication Date: 2025.10.16 MEDTRONIC MINIMED INC
  • US20250319254A1 patent drawing
  • US20250319254A1 patent drawing
  • US20250319254A1 patent drawing

AI summary

Techniques disclosed herein relate to managing operations of a dual-mode insulin delivery device that can operate in a manual insulin delivery mode and an automated closed-loop insulin delivery mode. In one example, a processor-implemented method includes obtaining insulin delivery data of an insulin delivery device collected while the insulin delivery device operates in a closed-loop mode, determining an updated value of a parameter of the insulin delivery device in a manual mode based on the insulin delivery data, and causing the insulin delivery device to deliver insulin in the manual mode based on the updated value of the parameter of the insulin delivery device, where the parameter of the insulin delivery device has separate values in the manual mode and the closed-loop mode.