Dual-Module Biomedical Chip for Multi-Organ Cell Detection
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Solution Overview
Problem
Existing biomedical detection chips can only detect one type of organ cell at a time, limiting the comprehensive understanding of patient conditions and hindering personalized and precision medicine.
Innovation Solution
A biomedical detection chip with dual detection modules, each comprising substrates with flowing channels, chambers, and electrode modules, allowing simultaneous detection of multiple organ cells and drug combinations using hydrogel fixation and electric field distribution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a single detection module is used, then the device structure is simple, but only one type of organ cell can be detected at a time
Solution Approach 1:
The detection chip is divided into multiple independent detection modules, each capable of detecting a specific type of organ cell. Each module includes its own flowing channel unit, chamber, and electrode group, allowing parallel detection of multiple cell types simultaneously while maintaining modular simplicity
Solution Approach 2:
Each detection module is designed with universal components that can detect different organ cell types. The flowing channel units, chambers, and electrode groups are configured to handle various cell types (liver, kidney, heart, etc.) through standardized interfaces and detection protocols
2Adaptability or versatility
If multiple detection modules are added to detect various organ cells, then the detection versatility is improved, but the device complexity increases
Solution Approach 1:
The chip is segmented into multiple independent detection modules that can be integrated in a standardized manner. Each module is self-contained with its own flowing channel units and electrode groups, reducing the complexity of integration while enabling multi-cell-type detection
Solution Approach 2:
Multiple detection modules are arranged in a nested or stacked configuration within the chip structure. The modules share common fluidic pathways and control systems where applicable, allowing compact integration of multiple detection functions without proportionally increasing overall device complexity
Data Source
AI summary
A biomedical detection chip includes a first detection module and a second detection module. The first detection module includes a first substrate and at least one first flowing channel unit including a first flowing channel in the first substrate, a first opening communicating with an end of the first flowing channel, a first chamber communicating with another end of the first flowing channel, and a second opening communicating with the first chamber. The second detection module, located under the first detection module, includes a second substrate and at least one second flowing channel including a second flowing channel in the second substrate, and third and fourth openings communicating with opposite ends of the second flowing channel. The second flowing channel includes a second chamber between third and fourth openings. The second opening corresponds to and communicates with the third opening, and the fourth opening is exposed from the first substrate.