Dual-Nostril Intranasal Delivery for Precise Brain Targeting
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Solution Overview
Problem
Existing intranasal drug delivery devices face challenges in accommodating anatomical variations, targeting precise deposition in the nasal cavity, and are difficult for users with motor or cognitive impairments to use reliably.
Innovation Solution
A dual nostril inserter with a columella engaging portion that allows for quick and reliable positioning of a dispensing element within the nasal cavity, utilizing a subject engaging portion to seat the device in an ejection zone, and a trigger mechanism for precise composition delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a device is designed with precision targeting capability for the nasal channel, then delivery precision is improved, but device complexity and difficulty of operation increase
Solution Approach 1:
The device employs self-aligning features including a bulbous distal tip that automatically centers within the nasal channel, and a collarette that engages with the columella to self-position the device. The spring-loaded dispensing mechanism self-adjusts to deliver composition without requiring manual positioning or complex user manipulation, thereby achieving precision delivery while maintaining ease of operation.
Solution Approach 2:
The device is divided into functionally independent segments: a positioning component (collarette engaging columella), a dispensing component (spring-loaded mechanism), and a delivery component (bulbous tip). This segmentation allows each component to perform its specific function optimally while simplifying the overall operation for the user.
2Adaptability or versatility
If a device is designed to accommodate anatomical variations in nasal channels, then adaptability is improved, but device complexity increases
Solution Approach 1:
The device incorporates adjustable parameters including a spring-loaded dispensing mechanism that adapts to different nasal channel dimensions, and a collarette with varying engagement depths to accommodate different columella positions. The bulbous tip diameter can be adjusted to fit different nasal channel sizes, allowing the same device design to adapt to diverse anatomical variations without requiring multiple device variants.
Solution Approach 2:
The device is designed as a universal intranasal delivery system that can accommodate various nasal channel anatomies through its self-aligning bulbous tip and adjustable collarette mechanism. This single device design serves multiple users with different nasal structures, eliminating the need for customized devices for each anatomical variation.
3Measurement precision
If a device requires precise insertion angle and depth positioning, then delivery precision is improved, but ease of operation deteriorates
Solution Approach 1:
The device automatically determines the correct insertion angle and depth through its self-aligning bulbous tip that centers within the nasal channel and its collarette that engages with the columella at the appropriate position. The spring-loaded mechanism self-adjusts to the correct insertion depth, eliminating the need for the user to manually control insertion angle and depth while maintaining precise delivery.
Solution Approach 2:
The device performs preliminary positioning actions through its self-aligning features before the actual dispensing occurs. The bulbous tip automatically centers and the collarette engages with the columella to establish the correct insertion angle and depth in advance, so that when the user activates the device, the composition is delivered with precision without requiring the user to have performed complex positioning maneuvers.
Data Source
AI summary
The present disclosure describes devices for intranasal delivery. The devices may have a housing with a dispensing element, and a positioning or trigger element coupled to the housing that engages a columella region of the subject to position the dispensing element within the nasal channel and limit its depth of insertion. The devices can also include two insertable portions, each for insertion into a nasal channel of the subject, and an actuator that delivers the composition from either or both of the insertable portions. The devices can be transitioned from a first configuration to a second configuration. Devices of the present disclosure may provide a convenient and effective way to deliver compositions intranasally and to accomplish lateralized delivery to targeted regions of the brain.