Dual-Pathogen Amine Therapeutics for Influenza-Aspergillus Infections
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Solution Overview
Problem
Current treatments for influenza virus and Aspergillus fumigatus superinfections are inadequate, with limited antiviral and antimycotic options, and there is a need for novel therapeutics to address the high morbidity and mortality associated with these infections, particularly in patients with weakened immune systems.
Innovation Solution
Development of an amine of general formula (I) and a carbonic acid adduct (KA) that target cellular factors involved in the replication and inflammation processes of influenza viruses and Aspergillus fumigatus, offering a single active ingredient to treat infections and superinfections.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If separate treatments are used for influenza virus and Aspergillus fumigatus infections, then each pathogen can be targeted with specific antiviral or antimycotic medications, but the treatment complexity increases and multiple medications are required
Solution Approach 1:
The patent combines antiviral and antimycotic activities into a single compound that can treat both influenza virus and Aspergillus fumigatus infections simultaneously, eliminating the need for multiple separate medications and reducing treatment complexity
Solution Approach 2:
The compound exhibits dual functionality by acting as both an antiviral agent against influenza viruses and an antimycotic agent against Aspergillus fumigatus, allowing one medication to address multiple pathogens
2Adaptability or versatility
If multiple active ingredients are used to treat superinfections with influenza viruses and Aspergillus spp., then broader pathogen coverage is achieved, but the availability and management of multiple medications becomes limited and difficult
Solution Approach 1:
The invention merges antiviral and antimycotic properties into a single active ingredient, providing broad pathogen coverage while simplifying medication management to a single agent rather than multiple drugs
3Reliability
If conventional antiviral and antimycotic medications are used separately, then specific pathogens can be targeted, but treatment options remain limited and resistance develops rapidly
Solution Approach 1:
The compound provides universal activity against both viral and fungal pathogens, expanding treatment options beyond conventional single-target medications while maintaining effectiveness against specific pathogens
Data Source
AI summary
The present invention relates to an amine (AM) according to general formula (I); a carbonic acid adduct (KA) and a pharmaceutical composition (PZ) for use in the treatment of Aspergillus fumigatus infections and superinfections with influenza viruses and Aspergillus spp.