Dual Pathway Therapeutic Delivery Device
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Solution Overview
Problem
Current medical treatments for diseases like pancreatic cancer and diabetes face challenges in delivering therapeutic agents effectively to target tissues due to variations in blood supply and anatomical complexities, leading to inefficiencies and health risks.
Innovation Solution
A dual pathway treatment delivery device with an implantable port that allows for systemic and localized perfusion through separate blood vessels, utilizing a dynamic occlusion device to prevent reflux and ensure high-pressure delivery of therapeutic agents directly to the target organ.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If systemic treatments are used to deliver therapeutic agents, then the treatment can reach the target tissue, but the effectiveness varies due to the treatment agent not reaching the target tissue efficiently and causing systemic side effects
Solution Approach 1:
The invention divides the treatment delivery system into two separate pathways: a first pathway for systemic perfusion and a second pathway for localized perfusion. This segmentation allows therapeutic agents to be delivered systemically when needed while enabling targeted local delivery to specific organs or tissues, thereby improving treatment effectiveness and reducing systemic side effects by concentrating therapy where it is most needed.
2Quantity of substance
If intra-arterial delivery is used to increase drug concentration at the tumor site, then higher drug concentration reaches the tumor, but there is variation in the number of cells actually introduced to the pancreas versus other organs
Solution Approach 1:
The invention segments the perfusion pathways by providing separate first and second pathways that can be independently controlled. The first pathway delivers therapeutic agents systemically while the second pathway provides localized delivery to a specific organ or tissue. This segmentation enables precise control over the quantity of cells or agents delivered to the target organ, ensuring accurate dosing and reducing variation in cell introduction to the pancreas versus other organs.
3Device complexity
If a single pathway is used for therapeutic agent delivery, then the device complexity is reduced, but the adaptability to different treatment needs (systemic vs. localized) is limited
Solution Approach 1:
The invention creates a multi-functional delivery system where a single device incorporates both a first pathway for systemic perfusion and a second pathway for localized perfusion. This universal design allows the same device to adapt to different treatment needs—delivering therapeutic agents systemically when broad coverage is required, or locally to specific organs when targeted therapy is needed—thereby enhancing versatility without requiring multiple separate devices.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enables precise and efficient delivery of therapeutic agents to target tissues, reducing systemic side effects and enhancing the concentration of drugs at the tumor site, thereby improving treatment outcomes for conditions like pancreatic cancer.
Implementation Method 1
When a second therapeutic agent is infused through the hub and into the second lumen, the infusion of the agent generates a relative higher fluid pressure on a distal side of the dynamic occlusion device than on a proximal side of the dynamic occlusion device
Data Source
AI summary
Methods are provided for delivering a treatment therapy to treat an organ diagnosed with a disease state. The methods include delivering a first therapeutic agent into systemic circulation at a first flow rate, and delivering a second therapeutic agent directly into a vessel feeding the organ at a higher second flow rate than the first flow rate in a manner that prevents the second treatment agent from circulating systemically.