Dual-Phase Biosensor for Early Disease Detection
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Solution Overview
Problem
Current methods for disease diagnosis are limited in their ability to detect diseases at an early stage, particularly before noticeable symptoms appear, and often require invasive procedures, which can be costly and burdensome.
Innovation Solution
A system and device that simultaneously analyze volatile and non-volatile organic compounds from biosamples, using a combination of liquid and gas phase sensors to identify unique disease signatures, allowing for early detection and monitoring of health status without invasive procedures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If current disease diagnosis methods are used, then diseases can be detected, but detection occurs at later stages and invasive procedures are required
Solution Approach 1:
The invention changes the detection parameter from analyzing only liquid-phase biomolecules to simultaneously analyzing both liquid-phase and gas-phase (VOC) components from the same sample. This dual-phase analysis enables earlier disease detection by capturing volatile metabolic byproducts that appear before noticeable symptoms, while using non-invasive sample collection methods
Solution Approach 2:
The system performs multiple functions simultaneously: it analyzes both volatile organic compounds (gas phase) and non-volatile biomolecules (liquid phase) from a single sample, providing comprehensive disease detection capability. This multi-functional approach allows early detection through VOC signatures while also maintaining the ability to detect later-stage disease markers in the liquid phase
2Measurement precision
If comprehensive health analysis is performed, then early detection accuracy improves, but device complexity increases
Solution Approach 1:
The invention merges volatile organic compound sensors and non-volatile biomolecule sensors into a single integrated analysis system. By combining both sensor types and analyzing both gas-phase and liquid-phase components simultaneously from one sample, the system achieves comprehensive disease detection accuracy without requiring separate testing procedures
Solution Approach 2:
The system segments the analysis into two parallel pathways: one for VOC detection in the gas phase and another for biomolecule detection in the liquid phase. This segmentation allows each sensor type to be optimized for its specific function while being coordinated through a unified control and data integration system
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables early detection of diseases, reduces the need for invasive medical procedures, and improves patient outcomes by providing a comprehensive picture of health status, thereby enhancing survivability and quality of life.
Implementation Method 1
gas emitted from the same sample interacts with the corresponding gas phase volatile organic compound (VOC) sensors
Data Source
AI summary
The present invention provides an improved system, method, and device for determining an individual's comprehensive state of health in real time. The invention described herein provides a more effective capacity for the early detection of disease by reading both volatile and non-volatile organic compounds simultaneously. This invention enables researchers, medical professionals, or users to fully understand the physiology of the individuals' samples being examined to include both signatures associated with a specific disease and the conditions which suggest an early preventive intervention or modulation of therapy is advised. Because this invention provides a completely non-invasive testing capability, it is ideally suited for longitudinal studies and continuous monitoring in the clinic.