Dual-Photometer Analysis Switching for Accurate Concentration Measurement
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Solution Overview
Problem
Existing automatic analysis devices face issues with selection errors and unclear criteria for switching between absorption and light scattering photometers, leading to inaccurate and inefficient measurement of component concentrations in specimens.
Innovation Solution
An automatic analysis device equipped with both absorption and light scattering photometers, utilizing a simultaneous absorption/scattering analysis method with defined calibration curves and switching criteria to prevent selection errors, allowing for high precision and speed in measuring component concentrations across various specimen concentrations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a light scattering photometer is used for low concentration specimens, then measurement sensitivity is improved, but quantitativeness deteriorates due to multiple scattering at high concentrations
Solution Approach 1:
The system dynamically switches between light scattering photometer and absorption photometer based on the concentration level of the specimen. For low concentration specimens, the light scattering photometer is used to achieve high sensitivity. For high concentration specimens, the absorption photometer is used to maintain quantitativeness and avoid multiple scattering effects.
Solution Approach 2:
The automatic analysis device is equipped with both light scattering photometer and absorption photometer, enabling it to perform both scattering detection and absorption photometry functions. This multi-functionality allows the system to handle both low concentration and high concentration specimens with appropriate measurement methods.
2Reliability
If an absorption photometer is used for high concentration specimens, then quantitativeness is improved, but measurement sensitivity deteriorates for low concentration specimens
Solution Approach 1:
The system dynamically selects the appropriate photometer based on specimen concentration. The absorption photometer is activated for high concentration specimens to ensure accurate quantitativeness, while the light scattering photometer is used for low concentration specimens to maintain measurement sensitivity.
Solution Approach 2:
By incorporating both absorption photometer and light scattering photometer in the same device, the system achieves universal capability to measure both low concentration and high concentration specimens with high accuracy, overcoming the limitations of using either photometer alone.
3Productivity
If photometer selection is based on pre-set concentration ranges, then measurement efficiency is improved, but selection errors occur due to unclear switching criteria
Solution Approach 1:
The system performs preliminary measurement using one photometer and then uses the measurement result as feedback to determine whether to switch to the other photometer. The switching decision is based on whether the preliminary measurement value falls within a predetermined concentration range, ensuring accurate and reliable photometer selection.
Solution Approach 2:
The system performs a preliminary measurement before final measurement to determine the appropriate photometer. This preliminary action allows the system to assess the specimen concentration and select the most suitable photometer before performing the actual quantitative measurement, preventing selection errors.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Accurate and rapid measurement of component concentrations is achieved by seamlessly switching between photometers, ensuring high precision and wide dynamic range without selection errors.
Implementation Method 1
an absorption photometric method for measuring a transmitted light amount of the specimen is used. In the absorption photometric method, a specimen or a reaction solution in which the specimen and a reagent are mixed is irradiated with light from a light source, absorbance is calculated by measuring the transmitted light amount
Implementation Method 2
absorbance is calculated by measuring the transmitted light amount of single or a plurality of wavelengths obtained as a result thereof, and a component amount of the desired component contained in the specimen is obtained from a relationship between the absorbance and the concentration according to the Lambert-Beer's law
Implementation Method 3
In a scattering detection method utilizing a change in light amount of the scattered light, the agglutination mass generated by the antigen-antibody reaction is irradiated with light, the light amount scattered by the agglutination mass and/or the scattered light intensity is measured
Implementation Method 4
a latex immunoturbidimetric method and the like capable of performing high sensitive measurement by increasing a size of an agglutination mass generated by an antigen-antibody reaction using a reagent sensitized (bound) to a surface of a latex particle with an antibody or an antigen to increase a turbidity change
Data Source
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AI summary
In order for the incidence of selection error, in which a photometer cannot be selected, to be prevented from occurring in an automatic analysis device provided with a plurality of types of photometers when the concentration of a desired component in various specimens is to be determined, an automatic analysis device 1 has a plurality of types of photometers 44, 45 having different quantitative ranges, and an analysis control unit 50 for quantifying the desired component in specimens on the basis of measurement values AL1, AL2 of one or more photometers selected from among the plurality of types of photometers 44, 45. The analysis control unit 50: sets a switching region RS in an overlap region of respective quantitative ranges C1, C2 of the plurality of types of photometers 44, 45, said switching region RS having a greater width than does the variation in quantitative values Ca, Cb of the desired component based on the measurement values AL1, AL2 of photometers 44, 45 having the same specimen; compares the quantitative value of a quantitative range portion that corresponds to the switching region RS and the quantitative values Ca, Cb of the desired component based on the measurement values AL1, AL2 of the photometers 44, 45; and selects a photometer to be used in quantitative output of the desired component from among the plurality of types of photometers 44, 45.