Dual-Polarization Conformal Filters for Real-Time Tumor Margin Imaging
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Solution Overview
Problem
Current spectroscopic imaging techniques for tissue analysis are limited by the need for multiple bandpass measurements, leading to prolonged measurement times and subjective histological evaluation, which complicates intraoperative tumor margin detection and increases the risk of cancer recurrence.
Innovation Solution
The development of an intraoperative optical diagnostic device utilizing dual polarization conformal filters that separate interacted photons into multiple optical paths, allowing for simultaneous or sequential detection of filtered components by multiple detectors, and a processor that applies voltages to filter stages to tune the filters in real-time, enabling rapid and objective analysis of tissue types.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple bandpass measurements are performed using conventional spectroscopic imaging techniques, then tissue type discrimination accuracy is improved, but measurement time is prolonged
Solution Approach 1:
The invention segments the spectrum into multiple bands using a stacked confocal filter assembly, where each filter stage transmits a specific wavelength band. This allows simultaneous multi-bandpass measurements rather than sequential scanning, reducing measurement time while maintaining tissue discrimination accuracy through parallel spectral information acquisition.
Solution Approach 2:
The invention transitions from temporal sequential measurement to spatial parallel measurement by stacking multiple confocal filters in different spatial positions within the optical path. Each detector array receives light filtered by a specific wavelength band simultaneously, converting a time-based measurement sequence into a space-based parallel architecture.
2Loss of information
If conventional spectroscopic imaging with sequential bandpass filtering is used, then comprehensive spectral information is obtained, but real-time intraoperative detection is compromised
Solution Approach 1:
The confocal filter assembly is pre-configured with multiple filter stages, each transmitting a specific wavelength band, before the measurement begins. This preliminary spectral decomposition allows immediate simultaneous detection across multiple bands without requiring sequential scanning during the actual measurement, enabling real-time intraoperative detection while preserving comprehensive spectral information.
Solution Approach 2:
The invention maintains continuous spectral measurement across all wavelength bands simultaneously through the stacked filter configuration, eliminating the interruptions and sequential delays inherent in conventional scanning methods. Multiple detector arrays continuously capture spectral information in parallel, ensuring uninterrupted real-time monitoring during surgical procedures.
3Productivity
If histological evaluation is performed subjectively by pathologists, then detailed tissue analysis is achieved, but objectivity and consistency are reduced
Solution Approach 1:
The invention replaces the mechanical/subjective process of histological evaluation by pathologists with an automated optical measurement system. The stacked confocal filter assembly combined with multiple detector arrays and computer-controlled voltage adjustment provides objective, quantifiable spectral data that eliminates human subjectivity while maintaining detailed tissue analysis capability through precise spectral characterization.
Solution Approach 2:
The system performs self-diagnosis by automatically analyzing spectral patterns and providing objective tissue classification without requiring subjective interpretation. The computer-controlled adjustment of filter stages and automated data processing enable the system to independently evaluate tissue types based on spectral signatures, ensuring consistent and reproducible results.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach reduces measurement time, enhances tissue type specificity, and provides real-time, objective diagnostic information during surgery, improving the detection of tumor margins and reducing the need for subsequent operations.
Implementation Method 1
dual polarization conformal filters that separate interacted photons into multiple optical paths
Implementation Method 2
confocal filters in a stacked configuration, each having multiple filter stages, each stage transmitting a different wavelength band
Implementation Method 3
Spectroscopic imaging combines digital imaging and molecular spectroscopy techniques including Raman scattering, fluorescence, photoluminescence, ultraviolet, visible and infrared absorption spectroscopies
Data Source
AI summary
Devices, systems, and methods for distinguishing tissue types are described herein. Such devices and systems may use dual polarization, conformal filters to acquire image data from target tissues and a processor to create an image in which the contrast between tissues has been enhanced.