Electrochemical test strip for testing multiple indicators, and testing method thereof
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Solution Overview
Problem
Existing electrochemical test strips can only detect a single sample indicator, requiring multiple blood samples for detecting multiple physiological indicators, which is painful, time-consuming, and cumbersome, and existing large biochemical equipment is expensive and not suitable for community health centers.
Innovation Solution
A dual-sided electrochemical test strip with two biosensors, each with its own electrode system and channel forming layer, allowing simultaneous detection of multiple indicators, including glucose, cholesterol, hemoglobin, uric acid, creatinine, urea, bilirubin, ketone body, and pH, using potentiometric and amperometric methods, with a sample addition port and notch design for rapid sample flow.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple single-indicator test strips are used to detect multiple physiological indicators, then detection coverage is improved, but patient discomfort and detection time increase due to multiple blood samples
Solution Approach 1:
The patent combines multiple single-indicator test strips into a single multi-indicator test strip by integrating multiple electrode systems (working electrodes, counter electrodes, reference electrodes) onto one substrate. Each electrode system detects a different physiological indicator (glucose, cholesterol, hemoglobin, uric acid, creatinine, urea, bilirubin, ketone body, pH), allowing simultaneous detection of multiple indicators from a single blood sample, thereby reducing both patient discomfort and detection time
Solution Approach 2:
The test strip is designed with multi-functionality to detect various physiological indicators including glucose, cholesterol, hemoglobin, uric acid, creatinine, urea, bilirubin, ketone body, and pH using the same device and single blood sample, eliminating the need for multiple specialized test strips
2Adaptability or versatility
If multiple single-indicator test strips are used to detect multiple physiological indicators, then detection coverage is improved, but operational complexity increases due to multiple sampling steps
Solution Approach 1:
The patent merges multiple detection functions into a single integrated test strip with multiple electrode systems that can simultaneously detect different physiological indicators from one blood sample application, reducing the number of operational steps and improving ease of use
Solution Approach 2:
The test strip is segmented into multiple independent electrode systems (each with working electrode, counter electrode, and reference electrode) that can independently detect different indicators, allowing the strip to handle multiple detection tasks simultaneously through a single sampling operation
3Measurement precision
If large biochemical equipment is used for detecting renal function indicators, then detection accuracy is improved, but device cost and accessibility worsen
Solution Approach 1:
The patent employs disposable test strips with integrated electrode systems that can detect renal function indicators (creatinine, urea, uric acid) along with other physiological parameters. These low-cost, single-use strips replace expensive large biochemical equipment, making accurate multi-indicator detection accessible in community health centers and primary care settings
Solution Approach 2:
The patent replaces complex mechanical and chemical assay systems of large biochemical analyzers with electrochemical detection using miniaturized electrode systems. The electrochemical method provides sufficient accuracy for clinical diagnostics while enabling compact, portable, and affordable device design
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid, accurate detection of multiple indicators with a single test, reducing patient discomfort and time, and facilitating use in portable devices, suitable for community health centers.
Implementation Method 1
A sample under detection passes through a channel forming area on the channel forming layer to react with the reaction reagent and generate a detectable signal
Implementation Method 2
a channel forming layer, and an upper cover, a sample under detection passes through a channel forming area on the channel forming layer
Data Source
AI summary
The present invention provides an electrochemical test strip (200) for detecting multiple indicators and a test method thereof. The electrochemical test strip includes a first biosensor (100) provided with an insulating substrate (1), a first electrode system, a first channel forming layer (4) and a first upper cover layer (5), and a second biosensor (101) provided with an insulating substrate (8), a second electrode system, a second channel forming layer (11) and a second upper cover layer (12). The first biosensor (100) and the second biosensor (101) are located on the front and back sides of the electrochemical test strip (200), respectively. A sample addition port (6) of the electrochemical test strip (200) is in liquid communication with a first channel forming area (55) of the first biosensor (100) and a second channel forming area (56) of the second biosensor (101), respectively.