Dual Vial Adapter Assemblage Simultaneous Venting
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Solution Overview
Problem
Existing dual vial adapter assemblages face issues with rapid transfer of liquid contents from a liquid vial to a drug vial, particularly when the drug vial is not under negative pressure, leading to incomplete or inefficient transfer due to leakage or insufficient negative pressure.
Innovation Solution
The dual vial adapter assemblage includes a vented drug vial adapter with a dual lumen drug vial stopper puncturing cannula and a vented liquid vial adapter with a dual lumen liquid vial stopper puncturing cannula, allowing for simultaneous venting and gravitational flow of liquid contents from the liquid vial into the drug vial, ensuring rapid transfer regardless of the drug vial's pressure status.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a negative pressure type dual vial adapter assemblage is used, then liquid contents can be positively drawn from liquid vial to drug vial, but the system requires specific mounting order and loses negative pressure if not properly assembled
Solution Approach 1:
The adapter assemblage is divided into separate male and female adapter components that can be independently assembled onto the vials. The male adapter with male connector attaches to the liquid vial first, then the female adapter with female connector attaches to the drug vial, allowing flexible mounting order while maintaining system integrity and negative pressure functionality.
2Ease of operation
If a gravitational flow type dual vial adapter assemblage is used, then mounting order is not restricted, but transfer of liquid contents takes longer and may be incomplete
Solution Approach 1:
The adapter design merges the advantages of both negative pressure and gravitational flow systems by incorporating a venting arrangement that allows air to be drawn into the liquid vial while liquid flows gravitationally. This simultaneous venting and flowing mechanism accelerates the transfer process while maintaining mounting flexibility, combining the speed of negative pressure systems with the operational ease of gravitational flow systems.
3Reliability
If venting arrangement is added to ensure sterile conditions during negative pressure operation, then filtered air can be drawn into drug vial, but device complexity increases
Solution Approach 1:
A filter element is introduced as an intermediary component within the venting arrangement. This filter allows air to pass through while blocking contaminants, maintaining sterile conditions in the drug vial. The filter is integrated into the female adapter structure, providing sterile protection without requiring separate complex venting mechanisms.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration enables rapid and complete transfer of liquid contents from a liquid vial to a drug vial, ensuring efficient reconstitution or mixing, even when the drug vial is not under negative pressure, and allows for quick release for infusion purposes.
Implementation Method 1
gravitational flow of liquid contents from the liquid vial into the drug vial
Implementation Method 2
simultaneous venting of the liquid vial through the dual lumen liquid vial stopper puncturing cannula's vented air lumen and the drug vial through the dual lumen drug vial stopper puncturing cannula's vented air lumen for assisting gravitational flow
Data Source
AI summary
Dual vial adapter assemblage for use with a drug vial and a liquid vial and including a vented drug vial adapter and a vented liquid vial adapter such that simultaneous venting of the liquid vial and the drug vial assists gravitational flow of liquid contents from the liquid vial into the drug vial for forming liquid drug therein.