Dual-Vial Semen Collection With 3:1 Stabilization Control
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Solution Overview
Problem
Existing semen analysis kits face challenges in maintaining consistent dilution ratios and sperm viability due to varying ejaculate volumes and time-sensitive nature of sperm, leading to inaccuracies in diagnostic processes, especially in at-home or mail-in testing scenarios.
Innovation Solution
A dual-vial system with a first vial for collecting neat semen and a second vial containing a stabilization medium, allowing a 3:1 dilution ratio and maintaining sample integrity, along with temperature control, to preserve semen viability for up to 72 hours.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a single vial with fixed volume of transportation medium is used, then the kit is simple to operate, but the dilution ratio varies with different ejaculate volumes leading to measurement inaccuracy
Solution Approach 1:
The single vial system is segmented into two separate vials: a first vial for collecting the semen sample and a second vial for containing the stabilization medium. This segmentation allows independent control of sample volume and medium volume, enabling consistent dilution ratios regardless of varying ejaculate volumes, thereby resolving the contradiction between operational simplicity and measurement precision.
2Manufacturing precision
If centrifugation is used to separate sperm from other components, then sample separation is achieved, but the process adds complexity and cost to the diagnostic procedure
Solution Approach 1:
The invention extracts the separation function from the diagnostic process by formulating a stabilization medium that naturally separates sperm from other components through density differences during storage, eliminating the need for centrifugation equipment and procedures. This reduces device complexity while maintaining the beneficial separation effect.
3Reliability
If immediate laboratory testing is required, then sperm viability is maintained, but logistical challenges arise in mail-in or at-home testing scenarios
Solution Approach 1:
The stabilization medium is prepared in advance in the second vial with optimal composition for preserving sperm viability. The medium includes stabilizing agents and buffers that maintain sperm function during extended storage and transport, allowing users to collect samples at home and mail them to the laboratory without compromising sperm viability, thus resolving the contradiction between reliability and logistical convenience.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Ensures consistent dilution concentration and extended sample viability, improving accuracy in semen analysis by allowing both original and homogenized samples for laboratory testing.
Implementation Method 1
a second vial having a predetermined volume of a stabilization medium
Data Source
AI summary
A dual-vial system, kit, and method for preservation of semen samples in mail-in semen analysis kits are described. The system comprises a dual-vial kit that comprises a first vial for collecting a semen sample of a subject, a second vial having a predetermined volume of a stabilization medium, and a transfer device for transferring a predetermined portion of the semen sample from the first vial to the second vial such that the transfer device has a volume allowing transfer of 1 part of the semen sample to be diluted in 3 parts of the stabilization medium in the second vial. Accordingly, the dual-vial kit enables preservation of semen viability for an extended period of up to 72 hours and carrying out of semen analysis within up to 72 hours of storing the semen in the stabilization medium.