Implantable Ductus Side-Entry Jacket for Targeted Drug Delivery
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Solution Overview
Problem
Conventional hemodialysis and apheresis methods are limited by the need for extracorporeal equipment, leading to short-term catheter use, high infection rates, and adverse side effects due to non-targeted drug delivery, and they require frequent clinic visits, which negatively impact the quality of life for patients with kidney failure and leukemia.
Innovation Solution
The development of ductus side-entry jackets and magnetic separation systems that allow for direct, targeted delivery of drugs and therapies within the body, reducing the need for extracorporeal equipment and minimizing adverse reactions by using magnetically susceptible carriers to extract and deliver substances directly to specific tissues or organs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional extracorporeal hemodialysis and apheresis equipment is used, then blood purification and drug delivery can be achieved, but the treatment requires frequent clinic visits and leads to short-term catheter use with high infection rates
Solution Approach 1:
The invention extracts the dialysis and apheresis function from extracorporeal equipment and relocates it to an intracorporeal implantable device. The implantable pump and separation chamber system performs blood purification and drug delivery directly within the body, eliminating the need for external machines and frequent clinic visits while reducing infection risks associated with repeated catheter access.
Solution Approach 2:
The invention introduces an intermediary implantable device that acts as a mediator between the bloodstream and drug delivery system. The implantable pump with separation chamber serves as an intermediary platform that can both purify blood and deliver drugs directly to target tissues, replacing the need for separate extracorporeal equipment and reducing systemic drug exposure.
2Object-affected harmful factors
If non-targeted drug delivery methods are used, then drugs can be administered systemically, but adverse side effects increase due to exposure of non-target tissues
Solution Approach 1:
The invention applies local quality by enabling site-specific drug delivery through the implantable system. The pump can deliver drugs directly to specific tissues or organs near the implant site, ensuring that only the target tissue receives the therapeutic agent while surrounding healthy tissues remain unaffected, thereby minimizing adverse side effects.
Solution Approach 2:
The invention replaces conventional systemic mechanical drug delivery (intravenous infusion) with a localized delivery mechanism. The implantable pump uses mechanical control to deliver drugs directly to the target site through a catheter or delivery channel, substituting the non-selective systemic circulation approach with a targeted local delivery system.
3Duration of action of stationary object
If short-term indwelling catheters are used for vascular access, then immediate access is achieved, but the catheters must be replaced frequently due to infection risks
Solution Approach 1:
The invention applies preliminary action by establishing a permanent implantable access device before treatment is needed. The implantable pump and catheter system can be implanted long-term, providing continuous vascular access without the need for repeated catheter insertions and removals, thereby eliminating the cyclic infection risk associated with short-term catheters.
Solution Approach 2:
The implantable system provides self-service by maintaining its own access point within the body. The implanted catheter and pump system creates a sealed, self-contained access pathway that does not require repeated breaches of the skin, allowing the system to serve itself continuously without external intervention for catheter replacement.
4Productivity
If frequent clinic visits are required for hemodialysis and apheresis, then blood purification can be performed, but patient quality of life deteriorates
Solution Approach 1:
The invention merges the blood purification function and drug delivery function into a single implantable device. The implantable pump system combines dialysis/apheresis capabilities with targeted drug delivery, allowing both functions to be performed continuously or periodically without requiring separate clinic visits for each treatment, thereby improving patient convenience while maintaining therapeutic effectiveness.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables long-term ambulatory vascular access, reduces infection and side effect risks, and improves patient quality of life by allowing continuous, targeted treatment with fewer clinic visits and reduced systemic drug exposure.
Implementation Method 1
using magnetically susceptible carriers to extract and deliver substances directly to specific tissues or organs
Data Source
AI summary
Described are means for the direct and continuous connection of a catheter to the lumen of any tubular anatomical structure, or ductus, without medically significant leakage. A port implanted at the body surface with piping to a periductal collar allows drug or radionuclide delivery that bypasses the upstream lumen. The port allows injection, infusion, aspiration, or attachment of an automatic ambulatory pump. A superparamagnetic nanoparticle carrier-bound drug, for example, can be introduced into the lumen to pass downstream until the particles, with or without the drug still bound, are drawn into the lumen wall by a magnetized jacket surrounding the ductus. Such constitutes a method of drug targeting whereby a segment of a vessel or the territory supplied by a branch of that segment can be circumscribed for exposure to the drug. A jacket with side-entry connector positioned in surrounding relation to a lesion requiring treatment can itself be magnetized.