Endoscopic Duodenal Mucosal Resection Device
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Solution Overview
Problem
Current methods for treating diabetes and related metabolic conditions, such as obesity and fatty liver disease, are invasive, irreversible, and associated with significant morbidity, and do not effectively target the duodenal mucosa and submucosa, which play a crucial role in glucose homeostasis and insulin resistance.
Innovation Solution
A device and method for endoscopically resecting the duodenal mucosa and submucosa using a cap with suction and resection components that change configuration to encircle and constrict tissue, reducing blood flow and allowing for the removal of diseased tissue without affecting the muscularis or serosa, thereby addressing the imbalance between anti-incretin and incretin factors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If bariatric surgery is performed to treat diabetes and obesity, then glycemic control and weight loss are improved, but the procedure becomes invasive, irreversible, and associated with significant morbidity
Solution Approach 1:
The patent replaces invasive surgical mechanisms with endoscopic mechanisms. Instead of performing surgical bypasses or resections through open or laparoscopic approaches, the system uses endoscopic delivery to position resection components within the duodenum, thereby achieving metabolic treatment effects while avoiding surgical invasiveness and associated morbidity
Solution Approach 2:
The patent segments the gastrointestinal tract intervention by specifically targeting the duodenal mucosa and submucosa rather than performing complete bowel resection or complex bariatric anatomy changes. This localized segmentation allows for precise treatment of the metabolic signaling center while preserving overall gastrointestinal function and avoiding irreversible anatomical alterations
2Reliability
If complete intestinal resection is performed to treat diabetes, then metabolic effects are achieved, but the procedure is irreversible and carries high surgical risk
Solution Approach 1:
The patent applies local quality by selectively removing only the duodenal mucosa and submucosa layers while preserving the muscularis propria and serosa. This localized resection of specific tissue layers with distinct functional properties achieves the desired metabolic effects through disruption of anti-incretin factor production, while avoiding the complexity and irreversibility of complete intestinal resection
Solution Approach 2:
The patent employs partial action by removing only the necessary portion of the duodenal wall (mucosa and submucosa) rather than performing complete resection. This partial resection is sufficient to achieve the therapeutic goal of modulating incretin and anti-incretin hormone secretion while avoiding excessive surgical intervention and its associated risks
3Productivity
If thermal ablation is used to remove duodenal mucosa, then tissue removal is achieved, but strictures, hemorrhage, and perforation occur
Solution Approach 1:
The patent substitutes thermal ablation mechanisms with mechanical resection mechanisms. Instead of using heat, cold, or electromagnetic energy to remove tissue, the system employs physical resection components that mechanically excise the duodenal mucosa and submucosa, thereby achieving efficient tissue removal while avoiding thermal-related complications such as strictures, hemorrhage, and perforation
Solution Approach 2:
The patent extracts the harmful thermal energy component from the tissue removal process and replaces it with a purely mechanical extraction approach. The resection components physically remove the targeted tissue layers without introducing thermal stress, thereby eliminating the risk of thermal damage while maintaining effective tissue removal
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach provides a less invasive, safer procedure with minimal complications, leading to improved glucose homeostasis, weight loss, and modulation of gut hormones, resulting in significant improvements in glycemic control and metabolic health without the need for extensive surgical intervention.
Implementation Method 1
a suction source configured to apply a negative pressure through the central lumen of the cap
Implementation Method 2
at least one resection component positioned around an outer surface of the cap, wherein the at least one resection component is configured to change from a first configuration when positioned on the cap to a second configuration once deployed
Data Source
AI summary
Methods and systems are provided for an endoscopic tissue resection and or tissue removal device for use with an endoscope. The distal end of the endoscope includes the resection device with one or more elastic bands and shape memory material anchors associated with each band. Post-deployment of a band from the distal end of the endoscope, the associated shape memory material provides an anchor into the target mucosal tissue that the deployed band is positioned to constrict.