Multilayer Dural Repair Material with Anti-Adhesion and Hemostasis

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Solution Overview

Problem

There is a need for a material that can mimic the functionality of the dura mater and possess satisfactory handling characteristics for repairing dural defects, which are often caused by surgical procedures, trauma, or congenital anomalies, and existing materials fail to adequately prevent adhesion and promote hemostasis.

Innovation Solution

A composite dural repair material comprising a non-porous layer with anti-adhesion properties, a porous layer with hemostatic properties, and a reinforcement member, where the non-porous layer is made from collagen-based materials and the porous layer is formed using collagen foams, and the reinforcement member is embedded within the non-porous layer or positioned between the layers.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing dural substitute materials are used to repair dural defects, then structural support is provided, but they fail to adequately prevent adhesion and promote hemostasis

Engineering Contradiction:

Improveadhesion prevention and hemostasis effectivenessVSAvoidfunctional characteristics matching dura mater

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The dural repair material is divided into three distinct functional layers: a non-porous layer for adhesion prevention, a porous layer for hemostasis promotion, and a reinforcement member for structural support. Each layer independently performs its specific function, resolving the contradiction by providing specialized functionality rather than relying on a single material to fulfill all requirements.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention combines multiple materials with different properties into a composite structure: collagen-based non-porous material for anti-adhesion, porous collagen foam for hemostasis, and reinforcement fibers or mesh for strength. This composite approach allows each material to contribute its optimal properties, achieving both reliable adhesion prevention/hemostasis and structural integrity.

Inventive Principle:

Principle #40Composite materials

2Adaptability or versatility

If a single-layer dural substitute is used, then the structure is simple, but it cannot simultaneously provide anti-adhesion, hemostatic, and reinforcement functions

Engineering Contradiction:

Improvemulti-functionality (anti-adhesion, hemostasis, reinforcement)VSAvoidnumber of layers and components

Core Design Contradiction:

Adaptability or versatilityVSDevice complexity

Solution Approach 1:

The device is segmented into three functional layers, each responsible for a specific function: non-porous layer for adhesion prevention, porous layer for hemostasis, and reinforcement member for structural support. This segmentation allows multi-functionality while maintaining clear functional separation.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention merges three distinct functional components into a single integrated composite material system. The layers are combined through embedding or lamination, creating a unified structure that provides anti-adhesion, hemostatic, and reinforcement functions simultaneously, rather than requiring separate applications of multiple materials.

Inventive Principle:

Principle #5Merging (Combining)

3Strength

If the reinforcement member is embedded within the non-porous layer, then structural strength is enhanced, but the anti-adhesion property may be compromised

Engineering Contradiction:

Improvestructural reinforcementVSAvoidadhesion formation

Core Design Contradiction:

StrengthVSObject-affected harmful factors

Solution Approach 1:

The non-porous layer is designed with localized properties: the region containing the embedded reinforcement member provides structural strength, while the exposed surface regions maintain smooth, non-porous characteristics for adhesion prevention. This local differentiation allows both strength enhancement and anti-adhesion properties to coexist without compromising either function.

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composite material effectively prevents tissue ingrowth and adhesion, promotes hemostasis, and provides structural reinforcement, thereby facilitating effective dural repair while maintaining biocompatibility and bioabsorbability.

Implementation Method 1

the non-porous layer is a collagen containing film possessing anti-adhesion properties

Methodology Applied

Scientific EffectAnti-adhesion property:

Implementation Method 2

the porous layer is a collagen containing foam that provides hemostatic properties

Methodology Applied

Scientific EffectHemostatic property:

Implementation Method 3

a liquid solution based on a collagenic constituent destined to form the non-porous layer is cast on a substrate... Prior to complete gelling

Methodology Applied

Scientific EffectGelling: Gel

Implementation Method 4

Upon drying, the various components adhere to form a dural repair material

Methodology Applied

Scientific EffectAdhesion: Adhesive

Data Source

PatentUS8932619B2Dural repair material

Publication Date: 2015.01.13 SOFRADIM PRODUCTION SAS

AI summary

Multilayer structures including a porous layer and a non-porous layer having a reinforcement member are useful as dural repair materials.