Dynamic Bolus Calculation Using Basal Rate Adaptation
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Solution Overview
Problem
Existing methods for calculating bolus insulin doses in insulin pumps often rely on abrupt, time-based constant values for parameters Ameal and Dcorrection, which do not accurately reflect individual patient needs and circadian fluctuations in basal insulin requirements.
Innovation Solution
A method and device that calculate bolus amounts based on the current basal rate, using formulas that incorporate the basal rate as a function of changing circadian rhythms, eliminating the need for abrupt parameter changes by using constant factors CFA and CFD derived from hourly basal rate values.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If constant values are preset for parameters Ameal and Dcorrection over preset periods based on time of day, then the calculation method is simple to implement, but the accuracy of bolus dose calculation deteriorates because it does not reflect individual patient needs and circadian fluctuations
Solution Approach 1:
The patent transforms the static constant parameters Ameal and Dcorrection into dynamic parameters that are continuously adapted based on the actual basal rate. The parameters are recalculated using the formula Ameal = CFA × BRactual and Dcorrection = CFD × BRactual, where BRactual represents the time-varying basal rate. This dynamic adaptation allows the bolus calculation to reflect circadian fluctuations and individual patient needs while maintaining computational simplicity through the use of constant factors CFA and CFD.
Solution Approach 2:
The patent changes the parameters Ameal and Dcorrection from fixed constant values to variable parameters that depend on the actual basal rate. By introducing the relationship between basal rate and these parameters through constant factors, the system achieves parameter adaptation without complex algorithms, resolving the contradiction between implementation simplicity and calculation accuracy.
2Device complexity
If abrupt parameter changes are used to account for circadian fluctuations, then the calculation remains computationally simple, but the stability of bolus dose recommendations deteriorates due to abrupt changes
Solution Approach 1:
The patent implements continuous dynamic adaptation of parameters Ameal and Dcorrection by linking them to the actual basal rate, which naturally varies smoothly over time. This approach replaces abrupt parameter changes with continuous adaptation, ensuring stable bolus recommendations that follow the physiological circadian rhythm without sudden jumps.
Solution Approach 2:
The system uses feedback from the actual basal rate to continuously adjust the parameters Ameal and Dcorrection. By using the formula involving BRactual (actual basal rate), the parameters are automatically adjusted based on real-time physiological data, providing stable and adaptive bolus calculations that respond smoothly to changing conditions.
3Ease of operation
If constant parameter values are used for bolus calculation, then the calculation method is easy to operate, but the adaptability to individual patient needs and circadian rhythms deteriorates
Solution Approach 1:
The patent transforms fixed parameters into adaptive parameters that automatically adjust to individual patient needs and circadian rhythms. The formulas Ameal = CFA × BRactual and Dcorrection = CFD × BRactual enable the parameters to vary continuously based on the patient's actual basal rate, providing personalized adaptation without complicating the operation.
Solution Approach 2:
The system enables self-service adaptation by automatically adjusting parameters based on the actual basal rate without requiring manual intervention. The constant factors CFA and CFD serve as pre-configured coefficients that allow the system to adapt to individual patient characteristics autonomously, maintaining ease of operation while achieving high adaptability.
Data Source
AI summary
A method for calculating a bolus amount, wherein the bolus amount is calculated according to a basal rate, and a device for calculating a bolus amount according to the method, the device including an input unit used to input an amount of received carbohydrates, a computer coupled to the input unit and at least one interface used to transmit an actual blood glucose value and the value of the actual basal rate to the computer, wherein the at least one interface or another interface transmits a bolus amount calculated by the computer.