Dynamic Bioactive Bone Graft Material for Customizable Shape and Handling
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Solution Overview
Problem
Current bone graft materials lack the necessary chemical and physical properties for optimal bone grafting, including variable porosity, differential resorption capacity, and ease of handling, and often pose risks such as disease transmission and complications from natural material harvesting.
Innovation Solution
Development of dynamic bioactive synthetic bone graft materials with varying levels of porosity (nano, micro, meso, macro) and differential bioresorbability, featuring bioactive glass fibers and particulates that can be molded into clinically relevant shapes, providing antimicrobial properties and drug delivery capabilities, and are designed to facilitate tissue formation through a physiologic process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If autograft materials are used for bone grafts, then acceptable physical and biological properties are achieved, but multiple or extended surgeries are required and considerable pain and morbidity occur at the donor site
Solution Approach 1:
The patent creates synthetic bone graft materials that replicate the physical and biological properties of natural autograft bone without requiring harvesting from the patient. The synthetic materials are designed to mimic the structural characteristics, porosity, and osteoconductivity of natural bone, providing the same regenerative benefits while eliminating donor site trauma and the need for additional surgical procedures
2Object-affected harmful factors
If allograft devices are used for bone grafts, then risk and pain to the patient are decreased, but increased risk of disease transmission and rejection occurs
Solution Approach 1:
The patent employs synthetic bone graft materials that are manufactured anew for each application rather than being harvested from donors. These synthetic materials eliminate the risk of disease transmission and immune rejection associated with allografts, while providing comparable mechanical support and osteoinductive properties. The materials are designed to be resorbable, gradually replaced by native bone tissue over time
3Reliability
If autograft and allograft devices are used, then bone grafting can be performed, but variations on shape and size are restricted
Solution Approach 1:
The patent describes synthetic bone graft materials with dynamic properties that allow them to be molded, shaped, and customized intraoperatively to match the specific anatomical defect. The materials can be formed into various shapes and sizes depending on the patient's needs, providing unlimited adaptability while maintaining structural integrity and promoting bone regeneration
4Reliability
If calcium phosphate materials are used for artificial bone grafts, then properties similar to natural bone are achieved, but ease of handling and flexibility are reduced
Solution Approach 1:
The patent modifies the physical and chemical parameters of calcium phosphate materials to improve their handling characteristics while preserving their bone-like properties. This includes adjusting porosity, particle size distribution, and incorporating binding agents that allow the material to be molded and shaped easily during surgery, transforming rigid calcium phosphate into a more versatile, formable graft material
5Strength
If calcium phosphate materials are made rigid to match natural bone, then structural strength is improved, but capacity to serve as liquid carrier/storage media is reduced
Solution Approach 1:
The patent incorporates porous structures within the calcium phosphate bone graft material, creating interconnected void spaces that can hold and release liquid biologics, growth factors, or antibiotics. This porous architecture maintains adequate structural strength for mechanical support while providing reservoirs for controlled drug delivery and enhancing the material's versatility as a carrier system
Data Source
Figure 1A~1B
Figure 2A~2C
Figure 3A~3B
AI summary
The present disclosure relates to a dynamic bioactive bone graft material and a method of handling the material to prepare an implant. In one embodiment, a method of preparing a dynamic bioactive bone graft implant is provided. The method includes the step of providing a porous, fibrous composition of bioactive glass fibers, wherein the fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and wherein the porosity of the matrix ranges from about 100 nanometers to about 1 millimeter. The porous, fibrous composition is introduced into a mold tray, and a shaped implant is created using the mold tray. The composition may be wetted with a fluid such as saline or a naturally occurring body fluid like blood prior to creating the shaped implant. In another embodiment, the porous, fibrous composition is provided with the mold tray as a kit.