Dynamic Bioactive Bone Graft with Engineered Porosity
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Solution Overview
Problem
Current bone graft materials lack optimal chemical and physical properties, such as controlled porosity, resorption rates, and ease of handling, which are essential for effective bone grafting, and they often require invasive procedures or carry risks like disease transmission and rejection.
Innovation Solution
Development of dynamic bioactive synthetic bone graft materials with engineered porosity, comprising bioactive glass fibers and particulates, allowing for varying levels of porosity, differential resorption, and antimicrobial properties, enabling flexible shaping and improved clinical handling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If autograft materials are used, then acceptable physical and biological properties are achieved, but multiple or extended surgeries are required and patient morbidity increases
Solution Approach 1:
The patent creates synthetic bone graft materials that replicate the essential biological and physical properties of natural bone without requiring harvesting from the patient. The synthetic materials are designed to mimic autograft characteristics while eliminating the need for donor site surgery, thereby reducing total surgical time and patient morbidity.
Solution Approach 2:
The invention modifies the chemical composition and structural parameters of synthetic materials to achieve bone-like properties. By adjusting parameters such as porosity, pore size distribution, and compositional ratios (e.g., calcium phosphate compositions), the materials replicate autograft behavior without requiring actual bone harvesting.
2Object-affected harmful factors
If allograft devices are used, then risk and pain to the patient is decreased, but risk of disease transmission and rejection increases
Solution Approach 1:
The patent develops synthetic bone graft materials that copy the beneficial low-risk profile of allografts while eliminating the harmful aspects of disease transmission and rejection. By using synthetically produced materials rather than processed donor bone, the invention achieves allograft-like safety without the biological risks of immunogenicity or pathogen transmission.
3Ease of operation
If calcium phosphate materials are made rigid for handling, then ease of handling is improved, but flexibility and capacity to serve as liquid carrier is reduced
Solution Approach 1:
The patent creates calcium phosphate materials with dynamic properties that can transition between rigid and flexible states. The materials are designed to maintain structural integrity for handling during surgery while simultaneously possessing the flexibility to serve as liquid carriers for delivering growth factors, antibiotics, or other therapeutic agents to the bone defect site.
Solution Approach 2:
The invention combines calcium phosphate materials with other substances to create composite structures that exhibit both rigidity for handling and flexibility for liquid carrier functions. These composites integrate the structural benefits of rigid calcium phosphate with the adaptability needed for drug delivery and fluid retention.
4Reliability
If porosity is increased to promote revascularization and healing, then bone growth is enhanced, but material strength is reduced
Solution Approach 1:
The patent employs porous calcium phosphate materials with specifically engineered pore structures that optimize both biological performance and mechanical strength. The pore size, distribution, and connectivity are controlled to promote cell infiltration, vascularization, and bone growth while maintaining sufficient structural integrity to support the bone defect during healing.
Data Source
AI summary
The present disclosure relates to a dynamic bioactive bone graft material having an engineered porosity. In one embodiment, a bone graft material is provided having bioactive glass fibers arranged in a porous matrix that is moldable into a desired shape for implantation. The material can be substantially without additives and can include at least one nanofiber. The porous matrix may include a combination of one or more pore sizes including nanopores, macropores, mesopores, and micropores. In another embodiment, a bone graft implant is provided having a matrix comprising a plurality of overlapping and interlocking bioactive glass fibers, and having a distributed porosity based on a range of pores provided in the bioactive glass fibers. The distributed porosity can comprise a combination of macropores, mesopores, and micropores, and the matrix can be formable into a desired shape for implantation into a patient.