Dynamic Hydrogel Filtration With Rotating Discs for Faster Purification
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Solution Overview
Problem
Conventional methods for dialysis of hyaluronic acid gels require high manual effort, decrease quality and reproducibility, increase production time and costs, and pose a risk of microbial contamination, while using toxic cross-linking agents like BDDE.
Innovation Solution
A method using a dynamic filtration device with semipermeable filter discs to remove unwanted molecules by concentrating and diafiltrating cross-linked biopolymer-based hydrogels at specific rotational speeds and pressures, reducing the presence of toxic cross-linker molecules like BDDE.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional dialysis methods are used to remove unwanted molecules from hyaluronic acid gels, then the gel can be purified, but the process requires high manual effort and time
Solution Approach 1:
The patent replaces manual mechanical dialysis operations with an automated dynamic filtration system that uses controlled rotational motion and pressure gradients to achieve purification, thereby reducing manual effort and process time while maintaining purification quality
Solution Approach 2:
The patent changes the operational parameters from static dialysis conditions to dynamic filtration conditions with controlled rotational speeds (20-500 1/min) and pressure ranges (0.5-6 bar), enabling faster purification while maintaining effectiveness
2Manufacturing precision
If conventional dialysis methods are used, then unwanted molecules can be removed, but production costs increase
Solution Approach 1:
The patent creates a controlled filtration environment with specific pressure and rotational conditions that prevent contamination and improve purification efficiency, reducing the need for extensive manual monitoring and lowering operational costs
Solution Approach 2:
By replacing labor-intensive manual dialysis with automated dynamic filtration equipment, the patent reduces operational costs while maintaining or improving purification quality through consistent, repeatable process conditions
3Manufacturing precision
If conventional dialysis is used, then purification can be achieved, but the risk of microbial contamination increases
Solution Approach 1:
The patent employs continuous filtration operation under controlled dynamic conditions, allowing for real-time removal of unwanted molecules and continuous monitoring, which reduces the time the gel is exposed to contamination risks compared to batch dialysis methods
Solution Approach 2:
The automated dynamic filtration system provides better control over process conditions and reduces manual handling, thereby lowering the risk of microbial contamination while maintaining effective purification
4Productivity
If high rotational speed and pressure are applied during filtration, then flux rates increase and process time decreases, but the gel structure may be compromised
Solution Approach 1:
The patent optimizes the rotational speed (20-500 1/min) and pressure range (0.5-6 bar) to achieve high flux rates while maintaining gel structural integrity, demonstrating that moderate dynamic conditions can simultaneously improve productivity and preserve material stability
Solution Approach 2:
The patent uses controlled dynamic filtration with rotational motion to enhance mass transfer and flux rates while the semipermeable membrane and controlled conditions protect the gel structure, achieving higher productivity without compromising structural stability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Significantly reduces unwanted molecules, maintains structural stability, decreases process time, and increases flux rates, achieving higher retentate concentration with improved efficiency and reduced contamination risks.
Implementation Method 1
dynamic filtration of a cross-linked biopolymer-based hydrogel using a dynamic filtration device which is equipped with semipermeable filter disc(s) to remove unwanted molecules
Implementation Method 2
concentrating the gel by applying a rotational speed within the range of 20 1/min to 500 1/min and a overpressure within the range of 0.5 to 6 bar
Implementation Method 3
dynamic filtration device which is equipped with semipermeable filter disc(s) to remove unwanted molecules
Data Source
AI summary
The present invention relates to a method for dynamic filtration of a cross-linked biopolymer-based hydrogel to remove unwanted molecules from the gel. In particular, the invention relates to dynamic filtration of a hyaluronic acid hydrogel using a dynamic filtration construction with rotating and semipermeable filter discs.