Dynamic Multi-Parameter Biological Data Visualization
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Solution Overview
Problem
Current methods for displaying multi-parametric data from flow cytometry are complex and inefficient, particularly as the number of parameters increases, leading to difficulties in visualizing and analyzing large datasets effectively.
Innovation Solution
A graphics control device and method for dynamically displaying multi-parametric data on a graphical user interface, which includes a plot generator that adjusts the size and shape of base objects and interactive controls based on cell measurements, allowing for interactive visualization of multiple parameters in a concise and contextual manner, using skyline plots and parallel coordinate plots.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If multi-parametric data is displayed using traditional 2D plots, then data visualization is simple, but the ability to represent complex high-dimensional relationships deteriorates
Solution Approach 1:
The patent transforms traditional 2D scatter plots into 3D visualizations by adding a vertical dimension that represents parameter importance or statistical significance. This allows multiple parameters to be simultaneously visualized while maintaining the ability to represent complex relationships through spatial positioning and elevation, resolving the contradiction between simplicity and information retention.
Solution Approach 2:
The patent implements nested circular displays where multiple parameter relationships are contained within hierarchical layers. Each circle represents a parameter, and nested circles show relationships between parameters, allowing complex multi-parametric data to be visualized in a compact, intuitive format that preserves contextual relationships while maintaining operational simplicity.
2Adaptability or versatility
If the number of parameters to be visualized increases, then the comprehensiveness of data analysis improves, but the complexity of the display system increases
Solution Approach 1:
The patent creates a universal display framework where a single 3D plotting system can handle any number of parameters by dynamically adjusting the vertical dimension and spatial relationships. The same basic visualization structure adapts to display 2 parameters or 20 parameters, eliminating the need for multiple specialized display systems and reducing overall complexity while maintaining comprehensiveness.
Solution Approach 2:
The patent implements dynamic visualization where the display automatically adjusts to the number of parameters being analyzed. The system dynamically repositions elements, adjusts scaling, and modifies the vertical dimension based on the input data, allowing the display complexity to scale gracefully with the number of parameters rather than requiring a fundamentally different system for each parameter count.
3Measurement precision
If detailed measurements for each parameter are displayed, then measurement precision improves, but the visual clutter and difficulty of interpretation increases
Solution Approach 1:
The patent applies local quality by displaying detailed measurement information selectively at specific locations in the visualization. Each parameter's detailed measurements are shown in its designated spatial region or nested circle, allowing precise data representation without overwhelming the entire display. Users can focus on specific parameter regions of interest while maintaining an overview of all parameters.
Data Source
AI summary
Data visualization features are described that provide a fast and accurate tool for displaying visualizations of high parameter data. The visualization features include graphically representing multiple parameters simultaneously with the associated statistical data for each parameter in an interactive way that maintains the contextual relationships between parameters and the related cell population. The visualization may be dynamically generated based on the measurements for the cell population and the resources available to the display device. The visualization features may be used for displaying high parameter multi-color flow cytometry or genomic data sets.