Neural Network ECGI MRI Integration for Cardiac Assessment
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Solution Overview
Problem
Current electrophysiology (EP) studies, including electrocardiographic imaging (ECGI), are invasive, time-consuming, and lack accuracy in revealing endocardial electrical activities of the heart, with high computational burdens hindering clinical applications.
Innovation Solution
Integration of ECGI information with magnetic resonance imaging (MRI) data using neural networks to generate a correlated, geometrically aligned representation of cardiac electrical and biomechanical properties, allowing for non-invasive prediction of target ablation locations and reducing the need for invasive procedures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If ECGI is used to measure cardiac electrical activities non-invasively, then the invasiveness is reduced, but the accuracy of revealing endocardial electrical activities deteriorates
Solution Approach 1:
The patent uses machine learning models as an intermediary to bridge the gap between non-invasive ECGI measurements and endocardial electrical activities. The ML model learns the mapping relationship from epicardial potentials (measured non-invasively) to endocardial electrical states, enabling accurate inference without direct endocardial measurement or invasive procedures.
Solution Approach 2:
The patent creates a virtual copy of the endocardial electrical activities through machine learning inference. Instead of directly measuring endocardial potentials (which would require invasive catheter insertion), the system generates a computational replica of endocardial electrical states based on non-invasive epicardial measurements and anatomical models.
2Measurement precision
If physics-based models are used for ECGI reconstruction, then the theoretical accuracy may be improved, but the computational burden increases significantly
Solution Approach 1:
The patent replaces complex physics-based computational models with machine learning models. Instead of solving forward and inverse electrocardiography problems using computationally intensive physics simulations, the system uses trained neural networks that rapidly infer electrical activities from measured data, dramatically reducing computational burden while maintaining accuracy.
Solution Approach 2:
The patent performs preliminary training of machine learning models using comprehensive physics-based simulations and labeled data. This preliminary action pre-computes the complex relationships between electrical activities and body surface potentials, so that during actual clinical use, only lightweight inference is needed rather than full physics-based reconstruction.
3Device complexity
If only ECGI information is used for cardiac assessment, then the simplicity of the assessment is maintained, but the comprehensiveness of cardiac information deteriorates
Solution Approach 1:
The patent merges ECGI electrical information with anatomical and structural data from other imaging modalities (such as CT or MRI). By combining multiple information sources into a unified computational model, the system achieves comprehensive cardiac assessment that includes both electrical activities and anatomical context without significantly increasing procedural complexity.
Data Source
AI summary
Described herein are neural network-based systems, methods and instrumentalities associated with cardiac assessment. An apparatus as described herein may obtain electrocardiographic imaging (ECGI) information associated with a human heart and magnetic resonance imaging (MRI) information associated with the human heart, and integrate the ECGI and MRI information using a machine-learned model. Using the integrated ECGI and MRI information, the apparatus may predict target ablation sites, estimate electrophysiology (EP) measurements, and/or simulate the electrical system of the human heart.


