Echocardiogram Synthesis With Myocardium Motion Modeling
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Solution Overview
Problem
Existing methods for synthesizing echocardiogram datasets lack myocardium motion modeling, limiting the development of deep learning models for echocardiogram analysis due to the high cost and time-consuming nature of manual annotation.
Innovation Solution
A method combining a video diffusion model and neural ordinary differential equations to synthesize echocardiogram datasets with myocardium motion modeling, using a video diffusion model to condition the segmentation map of the first frame and a neural ODE to estimate motion, enabling the propagation of segmentation maps through generated video frames.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If physics-based models are used to simulate myocardium motion, then motion modeling accuracy is improved, but device complexity and computational requirements increase
Solution Approach 1:
The patent combines a diffusion model (for image synthesis) with a neural ODE model (for motion estimation) into a unified framework. The diffusion model generates echocardiogram images while the neural ODE component estimates myocardium motion, and these two components are integrated to produce temporally coherent video sequences with accurate motion modeling, resolving the contradiction between motion accuracy and model complexity.
Solution Approach 2:
The neural ODE model acts as an intermediary between the diffusion model and the final video output. It estimates the motion field that transforms the first frame to subsequent frames, serving as a mediator that enables temporal coherence without requiring complex physics-based simulations throughout the entire generation process.
2Speed
If deep learning models are used for echocardiogram analysis, then analysis speed is improved, but data availability decreases due to limited annotated datasets
Solution Approach 1:
The patent uses the diffusion model to generate synthetic copies of echocardiogram video sequences with realistic myocardium motion. These synthesized datasets serve as artificial copies that augment the limited real annotated data, enabling deep learning models to be trained on larger datasets without requiring additional manual annotations, thus maintaining analysis speed while increasing data availability.
Solution Approach 2:
The system performs preliminary synthesis of annotated echocardiogram datasets before actual model training. By pre-generating synthetic training data with accurate motion modeling, the approach prepares sufficient training material in advance, eliminating the bottleneck of data availability that would otherwise slow down the development and deployment of deep learning models.
3Measurement precision
If manual annotation by expert cardiologists is used, then annotation accuracy is improved, but time consumption and cost increase
Solution Approach 1:
The diffusion model with neural ODE enables self-service annotation by automatically generating synthetic echocardiogram videos with realistic motion patterns. The system serves itself by producing annotated training data without requiring external expert cardiologists, thereby maintaining data quality while eliminating the time and cost associated with manual annotation.
Solution Approach 2:
Instead of manually annotating each real echocardiogram, the system creates synthetic copies with automatic annotations embedded during generation. These copied datasets provide the necessary training labels without the time-consuming manual process, preserving annotation accuracy through the physics-informed motion modeling while dramatically reducing annotation time.
Data Source
AI summary
Disclosed are a method and a system for synthesizing echocardiogram video segments with myocardium motion modeling using a combination of diffusion model and neural ordinary differential equations. The method includes the steps of: synthesizing the video echocardiography video that conditions the segmentation map of the first frame of the cardiac cycle (end-diastole) using a video diffusion model; estimating the motion, or a diffeomorphic registration between a given frame from generated video and the first frame of the cardiac cycle using a neural ordinary differential equation (ODE) model; and obtaining an annotated echocardiogram video by propagating the segmentation map of the first frame of the cardiac cycle through the generated video using the estimated motion.


