Extracellular Matrix Bioadhesive Adhesion Strength
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Solution Overview
Problem
Current bioadhesives face challenges such as weak adhesion in aqueous environments, toxicity, immune responses, low adhesion ability, and hindering of tissue regeneration and self-healing.
Innovation Solution
Development of an extracellular matrix-based bioadhesive using a hydrogel with gelatin properties, combined with a gelatin curing agent like ruthenium and sodium persulfate, which is applied and cured using visible light to enhance adhesive strength and bioactivity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If synthetic polymer-based bioadhesives are used, then adhesion strength is improved, but toxicity and immune responses increase
Solution Approach 1:
The patent changes the chemical composition parameters by using natural polymers (collagen, chitosan, alginate, gelatin) instead of synthetic polymers, and controls molecular weight, crosslinking density, and functional group content to achieve both strong adhesion and biocompatibility
Solution Approach 2:
The patent creates composite bioadhesive formulations by combining multiple natural polymer components (e.g., collagen with chitosan, or alginate with gelatin) to synergistically enhance adhesion strength while maintaining low toxicity and immune response
2Object-affected harmful factors
If fibrin-based bioadhesives are used, then side effects are reduced, but adhesion ability becomes very low
Solution Approach 1:
The patent merges fibrin-based components with other natural polymer systems (collagen, chitosan, alginate, gelatin) to create composite formulations that combine the low immunogenicity of fibrin with the enhanced adhesion properties of the additional polymer components
3Strength
If conventional bioadhesives are used, then adhesion is achieved, but tissue regeneration and self-healing are hindered
Solution Approach 1:
The patent incorporates bioactive components that enable self-healing functionality, where the bioadhesive can autonomously repair damage through embedded repair mechanisms such as self-assembling peptide structures or enzymatic crosslinking that reactivate after injury
Solution Approach 2:
The patent optimizes degradation rate parameters, porosity, and mechanical properties to match the natural tissue healing process, allowing the bioadhesive to provide temporary support while progressively degrading as tissue regeneration occurs
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The extracellular matrix-based bioadhesive exhibits excellent tissue bioadhesive ability, supports tissue regeneration, and provides a strong adhesive strength, about 2 to 6 times higher than fibrin glue, while minimizing cytotoxicity and immune responses.
Implementation Method 1
a gelatin curing agent like ruthenium and sodium persulfate, which is applied and cured using visible light
Data Source
AI summary
An embodiment of the present disclosure provides an extracellular matrix-based bioadhesive as an adhesive in the form of a composition including an extracellular matrix-containing hydrogel and a gelatin curing agent, wherein the extracellular matrix-containing hydrogel is gelatinized. Since the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure has the same or similar rheological properties as gelatin, the bioadhesive has flowability at a temperature of 30° C. or higher and may be evenly and easily applied to a lesion site in the body. In addition, the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure may adhere well to the lesion site because of a level of adhesive strength that is about 2 to 6 times higher than that of fibrin glue used as a commercial tissue adhesive. In addition, the extracellular matrix-based bioadhesive according to an embodiment of the present disclosure is based on a tissue-derived extracellular matrix, and thus includes a tissue-derived wound healing component or a tissue regeneration component, and may be used for wound healing or tissue regeneration in addition to bioadhesive applications.