ECM Cardiovascular Prostheses for Tissue Regeneration
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Solution Overview
Problem
Current cardiovascular prostheses face challenges such as thrombosis, intimal hyperplasia, harsh biological responses, biofilm formation, inflammation, and infection, and fail to induce site-specific tissue regeneration and remodeling effectively.
Innovation Solution
Development of biodegradable and remodelable cardiovascular prostheses comprising ECM compositions from mammalian tissue sources, combined with biologically active agents and pharmacological agents like growth factors and statins, to induce neovascularization and tissue regeneration without adverse inflammatory responses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If conventional prosthesis materials (metallic mesh, synthetic mesh) are used, then structural strength and inertness are improved, but susceptibility to infection, fragmentation, and harsh biological responses worsens
Solution Approach 1:
The patent employs composite materials combining acellular extracellular matrix (ECM) with biologically active agents and pharmacological agents. This composite structure provides both mechanical support and biological functionality, reducing infection susceptibility and adverse biological responses while maintaining structural integrity.
Solution Approach 2:
The patent modifies material parameters by using biodegradable polymers with controlled degradation rates, adjusting mechanical properties to match native tissue while providing temporary structural support. This allows the prosthesis to gradually transition from load-bearing to biologically integrated state.
2Adaptability or versatility
If multi-sheet laminate ECM structures are used, then tissue regeneration and remodeling are improved, but delamination occurs
Solution Approach 1:
The patent uses a multi-layer laminate structure where sheets are nested together with adhesive bonding. Each layer serves specific functions (structural support, cell infiltration, tissue ingrowth) while maintaining overall structural integrity through hierarchical organization.
Solution Approach 2:
The patent applies adhesive treatment to sheet surfaces before assembly to prevent delamination. This preliminary bonding action ensures structural stability is established before the prosthesis is implanted, preventing layer separation during tissue regeneration.
3Ease of manufacture
If polypropylene mesh structures are used, then ease of manufacture and tensile strength retention are improved, but distortion and separation from surrounding tissue due to scar contracture worsens
Solution Approach 1:
The patent uses thin, flexible ECM-based sheets that can conform to irregular tissue surfaces. These flexible structures adapt to scar contracture and tissue movement while maintaining intimate contact with surrounding tissues, preventing distortion and separation.
4Reliability
If ePTFE mesh structures are used, then chemical inertness and resistance to physical modification are improved, but macromolecular drainage is blocked in contaminated wounds worsening infection treatment
Solution Approach 1:
The patent employs porous ECM structures with controlled pore sizes that allow macromolecular drainage while maintaining structural integrity. The porous architecture enables fluid and cellular infiltration, facilitating infection management and tissue regeneration simultaneously.
Data Source
AI summary
Cardiovascular prostheses for treating, reconstructing and replacing damaged or diseased cardiovascular tissue that are formed from acellular extracellular matrix (ECM). The cardiovascular prostheses comprise various compositions, such as ECM based compositions, and structures, such as particulate structures, mesh constructs, encasement structures, coated structures and multi-sheet laminate structures.