Biodegradable ECM Polymer Composition for Tissue Regeneration
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing extracellular matrix materials for tissue regeneration and wound healing lack the ability to effectively induce and support new tissue growth and healing, particularly in response to physiological conditions, and require improved biodegradability and therapeutic components.
Innovation Solution
A biodegradable polymer composition comprising particulate extracellular matrix derived from mammalian tissues, combined with therapeutic agents and a liquid medium, which can change consistency in response to physiological conditions and degrade at a predetermined rate, supported by concentric tubes or sandwich configurations to enhance tissue regeneration and wound healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If extracellular matrix materials are used for tissue regeneration, then tissue repair function is provided, but the ability to effectively induce and support new tissue growth is insufficient
Solution Approach 1:
The patent combines extracellular matrix materials with biodegradable polymers to create a composite composition that maintains the biological activity of the ECM while adding structural support and controlled degradation properties. This composite approach enhances both tissue regeneration effectiveness and adaptability to physiological conditions through the synergistic properties of the combined materials.
Solution Approach 2:
The patent modifies the physical and chemical parameters of the extracellular matrix by incorporating biodegradable polymers with specific degradation rates. This allows the composition to adapt its properties over time in response to physiological conditions, improving both reliability and adaptability simultaneously.
2Duration of action of moving object
If biodegradable polymer compositions are designed to degrade at predetermined rates, then controlled degradation is achieved, but material stability during storage and handling is compromised
Solution Approach 1:
The patent incorporates stabilizing agents and protective formulations in advance during the composition preparation and packaging stages. These preliminary protective measures maintain material stability during storage and handling, while the controlled degradation properties remain intact for when the composition is deployed for tissue regeneration.
3Reliability
If therapeutic agents are added to enhance tissue growth, then regenerative capability is improved, but risk of bacterial growth and contamination increases
Solution Approach 1:
The patent incorporates antimicrobial agents alongside therapeutic agents in the composition. The antimicrobial components convert the potential harm of bacterial contamination into a protective benefit, allowing therapeutic agents to enhance tissue growth without increasing bacterial growth risk.
4Reliability
If complex compositions with multiple components are used to support tissue regeneration, then regenerative support is enhanced, but manufacturing complexity and cost increase
Solution Approach 1:
The patent combines multiple functional components (extracellular matrix, biodegradable polymers, therapeutic agents, and stabilizers) into a single integrated composition that can be manufactured as a unified product. This merging approach maintains the enhanced regenerative support of multiple components while simplifying manufacturing processes and reducing overall complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides effective tissue regeneration and wound healing by supporting new tissue growth, adapting to physiological conditions, and degrading at a controlled rate, thereby facilitating seamless integration and minimizing scarring.
Implementation Method 1
a biodegradable polymer composition comprising a particulate biodegradable polymer, particulate extracellular matrix (ECM), a therapeutic component and a liquid medium
Implementation Method 2
degrade at a predetermined rate
Implementation Method 3
which can change consistency in response to physiological conditions
Data Source
AI summary
The invention is a biodegradable polymer composition comprising a particulate biodegradable polymer, particulate extracellular matrix (ECM) derived from a mammalian tissue source, a therapeutic component that abates growth of bacteria and a liquid medium. The biodegradable polymer can change quality upon contact with a physiological parameter, such as temperature or pH that causes, for example, a liquid polymer to gel or harden. The polymer composition is adapted to induce regeneration of tissue in vivo.