Oral Edaravone Administration Timing for Consistent Absorption

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Edaravone, used as a therapeutic agent for ALS, is currently only available in injectable form and its oral administration is affected by meal types, leading to variations in pharmacokinetics.

Innovation Solution

Administering edaravone orally or intragastrically with specific time intervals after meals, such as 8 hours after a high-fat meal, 4 hours after a standard meal, or 2 hours after a light meal, to minimize meal effects on its pharmacokinetics.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If edaravone is administered orally without specific timing restrictions, then ease of operation is improved, but manufacturing precision deteriorates due to variability in drug absorption and concentration

Engineering Contradiction:

Improveease of oral administrationVSAvoidprecision of drug absorption

Core Design Contradiction:

Ease of operationVSManufacturing precision

Solution Approach 1:

The patent applies preliminary action by establishing specific timing conditions before administration (fasting for 10 hours or more, or specific intervals after meals) to ensure optimal absorption conditions are met before the drug is taken, thereby controlling absorption variability while maintaining oral administration

Inventive Principle:

Principle #10Preliminary action

2Ease of operation

If edaravone is administered immediately after meals, then ease of operation is improved, but reliability deteriorates due to inconsistent pharmacokinetic parameters

Engineering Contradiction:

Improveconvenience of administration timingVSAvoidreliability of therapeutic effect

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent establishes preliminary conditions regarding meal timing and composition before administration, requiring specific intervals (2-8 hours depending on meal type) to elapse before taking the drug, ensuring reliable pharmacokinetic parameters while allowing flexible administration timing

Inventive Principle:

Principle #10Preliminary action

3Manufacturing precision

If edaravone is administered with strict fasting requirements, then manufacturing precision is improved through consistent absorption, but ease of operation deteriorates due to dietary restrictions

Engineering Contradiction:

Improveconsistency of drug absorptionVSAvoidflexibility of administration

Core Design Contradiction:

Manufacturing precisionVSEase of operation

Solution Approach 1:

The patent provides multiple preliminary timing options (10-hour fast, 8-hour post-high-fat meal, 4-hour post-standard meal, 2-hour post-light meal) that all achieve consistent absorption, giving patients flexibility in choosing when to take the drug while maintaining manufacturing precision

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent changes the parameter of fasting duration based on meal type and composition, allowing shorter fasting periods after light meals compared to high-fat meals, thereby maintaining absorption consistency while improving administrative flexibility

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS20260048038A1Pharmaceutical composition for oral administration of edaravone and method of administering same

Publication Date: 2026.02.19 SHIONOGI INC

AI summary

A method of treating an oxidative stress disease includes orally or intragastrically administering, to a subject in need thereof, a pharmaceutical composition including edaravone with a time interval from a consumption of a meal by the subject in need thereof to an administration of the pharmaceutical composition to the subject in need thereof. The time interval is 8 hours or longer after the consumption of a high-fat meal, the time interval is 4 hours or longer after the consumption of a standard meal, or the time interval is 2 hours or longer after the consumption of a light meal.