Lentinula edodes Ergosterol Whitening Composition

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Solution Overview

Problem

Current skin whitening agents, such as ascorbic acid and kojic acid, have insufficient whitening effects and safety concerns, limiting their use in cosmetics and medicine.

Innovation Solution

A skin external composition containing ergosterol-based compounds, specifically 3β, 5α-dihydroxy-6β-methoxy-(22E, 24R)-ergosta-7,22-diene and 3β, 5α, 9α-trihydroxy-(22E, 24R)-ergosta-7,22-diene-6-one, extracted from Lentinula edodes, which provide remarkable whitening effects while being safe for the skin.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional whitening agents (ascorbic acid, kojic acid, hydroquinone) are used, then whitening effect is achieved, but safety problems for the skin occur

Engineering Contradiction:

Improvewhitening effectVSAvoidskin safety

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical structure parameters by using ergosterol-based compounds (3β, 5α-dihydroxy-6β-methoxy-(22E, 24R)-ergosta-7,22-diene and 3β, 5α, 9α-trihydroxy-(22E, 24R)-ergosta-7,22-diene-6-one) extracted from Lentinula edodes, which have different chemical properties compared to traditional whitening agents, achieving both whitening effect and skin safety

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs natural ergosterol-based compounds from mushroom extract as alternative whitening agents that provide safe and effective whitening without the harmful side effects of conventional synthetic whitening agents like hydroquinone and high concentrations of kojic acid

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Reliability

If traditional whitening agents are combined in cosmetic ingredients, then whitening effect is enhanced, but formulation safety problems occur

Engineering Contradiction:

Improvewhitening effectVSAvoidformulation safety

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent extracts and isolates specific active compounds (ergosterol-based compounds) from Lentinula edodes mushroom, purifying them to obtain safe and effective whitening agents that can be formulated without the harmful interactions associated with combining multiple traditional whitening agents

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent uses composite formulation approaches by combining ergosterol-based compounds with safe cosmetic ingredients, creating a formulation that maintains whitening efficacy while ensuring formulation safety through careful selection of compatible components

Inventive Principle:

Principle #40Composite materials

Data Source

PatentUS9901525B2External use skin composition, containing <i>Lentinula edodes</i>-derived ergosterol

Publication Date: 2018.02.27 AMOREPACIFIC CORP

AI summary

The present invention relates to a skin external composition, containing a Lentinula edodes-derived material, and more specifically, to an external use skin preparation composition containing an ergosterol-based compound obtained by being isolated from a Lentinula edodes extract and purified, thereby showing remarkable whitening effects.