Non-invasive EDPVR Calculation via Diastasis Pressure-Volume Modeling
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Solution Overview
Problem
Current methods for assessing the end-diastolic pressure-volume relationship (EDPVR) are invasive, limiting their clinical application in monitoring heart health, particularly in cases of heart failure where diastolic dysfunction is a concern.
Innovation Solution
A non-invasive method using ultrasound data to determine the end of diastasis volume and pressure in the left ventricle and atrium, generating a linearized ventricular pressure-volume relationship to calculate the EDPVR, which can be linked to experimental data for accurate assessment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If invasive catheterization is used to measure ventricular pressure for determining EDPVR, then measurement precision is improved, but ease of operation deteriorates due to the invasive nature limiting clinical application
Solution Approach 1:
The patent uses an intermediary approach by estimating ventricular pressure through a pressure-volume relationship model rather than direct measurement. The system employs an exponential function P = a*exp(b*V) that relates pressure to volume, allowing indirect determination of pressure values from non-invasive volume measurements combined with fitted parameters a and b, thus avoiding invasive catheters while maintaining measurement accuracy
Solution Approach 2:
The patent replaces the mechanical invasive catheterization system with a computational model-based approach. Instead of physically inserting pressure sensors into the ventricle, the system uses mathematical modeling and non-invasive imaging data to calculate pressure-volume relationships, substituting direct mechanical measurement with computational estimation
2Ease of operation
If non-invasive methods are used to measure EDPVR, then ease of operation is improved, but measurement precision deteriorates due to the inability to directly measure ventricular pressure
Solution Approach 1:
The patent applies preliminary action by performing offline fitting of the pressure-volume relationship model using available data to determine parameters a and b before actual EDPVR measurement. This pre-calibration step creates a customized pressure-volume curve for each patient, improving subsequent measurement accuracy by establishing subject-specific relationships rather than using generic assumptions
Solution Approach 2:
The patent utilizes parameter changes by transforming the non-linear pressure-volume relationship into a linearizable form through logarithmic transformation. By fitting the exponential model P = a*exp(b*V) and extracting parameters a and b, the system can then accurately predict pressure at any volume point along the EDPVR curve, converting a complex non-linear measurement problem into a manageable parameter estimation problem
Data Source
AI summary
The invention provides a method for calculating an end-diastolic pressure-volume relationship. The method includes obtaining a cardiac input representing a region of interest, wherein the region of interest comprises a left ventricle and a left atrium of a subject. An end of diastasis volume of the left ventricle is then determined based on the cardiac input, wherein diastasis is a stage of diastole during a heart cycle before atrial contraction. Further, an end of diastasis pressure in the left atrium is determined based on the cardiac input and a linearized ventricular pressure-volume relationship is generated based on the end of diastasis volume of the left ventricle and the end of diastasis pressure in the left atrium. An end-diastolic pressure-volume relationship is then determined based on an end-diastolic volume of the left ventricle and the linearized ventricular pressure-volume relationship.