Stable Liquid EGF Spray with Adhesive Polymer
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Solution Overview
Problem
Conventional treatments for stomatitis, especially those caused by chemotherapeutic or radioactive treatments, are ineffective and require long administration periods, and existing liquid formulations of epidermal growth factor are unstable due to the use of aqueous media, leading to decreased stability and convenience issues.
Innovation Solution
A stable liquid composition for treating stomatitis is developed, incorporating an epidermal growth factor, an adhesive polymer, and stabilizers such as EDTA, dextran, and certain amino acids, which improves the physicochemical and biological stability of the epidermal growth factor and allows for a spray formulation that can be quickly attached to oral inflammation sites.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If epidermal growth factor is formulated in a liquid type for spray application, then convenience of administration is improved, but stability of the epidermal growth factor decreases due to use of aqueous medium
Solution Approach 1:
The patent introduces a stabilizer as an intermediary substance that mediates between the aqueous medium and the epidermal growth factor. This stabilizer protects the epidermal growth factor from degradation while allowing the liquid formulation to maintain its spray application advantages. The stabilizer acts as a protective intermediary that enables both convenience and stability to coexist.
Solution Approach 2:
The patent creates a composite liquid formulation combining the epidermal growth factor, stabilizer, and aqueous medium into a single stable composition. This composite material approach allows the formulation to maintain the beneficial properties of each component while achieving overall stability, resolving the contradiction between liquid formulation convenience and protein stability.
2Ease of operation
If conventional mouth wash administration is used for stomatitis treatment, then simplicity of administration is maintained, but curative effect is low and administration period is long
Solution Approach 1:
The patent changes the key parameters of the formulation by incorporating a stabilizer that significantly enhances the biological activity and stability of the epidermal growth factor. This parameter change transforms the formulation from a simple mouth wash into a highly effective treatment that achieves rapid curative effects while maintaining ease of administration through spray application.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The stable liquid composition maintains effectiveness for a long period, providing rapid attachment and prolonged pharmaceutical effect when used as a spray, with improved stability against thermal and physical stress, and a favorable sensory experience for patients.
Implementation Method 1
a stabilizer selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, histidine, lysine and inorganic acid salts thereof, arginin and inorganic acid salts thereof, and dextran
Implementation Method 2
an adhesive polymer
Data Source
AI summary
Provided is a liquid composition for treating stomatitis, the liquid composition including: an epidermal growth factor; an adhesive polymer; and at least one stabilizer selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, histidine, lysine and inorganic acid salts thereof, arginin and inorganic acid salts thereof, and dextran. The liquid composition includes a stabilizer selected from EDTA (or salts thereof) and a certain amino acid (or inorganic acid salts thereof) and thus, physicochemical and biological stability of the epidermal growth factor can be substantially increased. Thus, the liquid composition can be stored and distributed for a long period of time. The stabilized composition includes an adhesive polymer, and thus, when ejected in a spray form in the mouth of a user, the liquid composition can be quickly attached to an inflammation site and exhibits effectiveness for a long period of time.