Egg Membrane Apheresis Filter for Residual Platinum Removal
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Solution Overview
Problem
Current therapeutic apheresis methods do not effectively eliminate residual platinum from cancer patients' blood after chemotherapy, posing a risk of long-term toxicity without using additional molecules or drugs that could harm essential organs.
Innovation Solution
A therapeutic apheresis filter using egg membrane particles in granulated or powdered form, housed in a macroparticle filtration membrane, adsorbs platinum molecules through ion exchange, ensuring their retention within the filter.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional apheresis filters are used, then blood can be filtered for common substances, but residual platinum cannot be eliminated from cancer patients' blood
Solution Approach 1:
The patent changes the chemical composition parameter of the filter material from conventional synthetic polymers to eggshell membrane particles, which contain specific proteins and amino acids that have high affinity for platinum ions. This parameter change enables the filter to selectively bind and remove platinum from blood while maintaining biocompatibility.
Solution Approach 2:
The patent uses a composite structure combining eggshell membrane particles with a biocompatible support matrix. The eggshell membrane provides platinum-binding functionality while the support matrix provides structural integrity and flow characteristics, creating a composite material that achieves both effective platinum removal and safe blood compatibility.
2Object-affected harmful factors
If chelators are used to block heavy metal effects, then some metals can be neutralized, but no technique exists to reduce heavy metals through therapeutic apheresis
Solution Approach 1:
The patent extracts the harmful platinum ions from the blood system by introducing eggshell membrane particles that selectively bind platinum. The bound platinum is then physically removed from the circulation through the apheresis process, effectively taking out the toxic substance from the body without requiring complex chemical neutralization steps.
Solution Approach 2:
The eggshell membrane particles act as an intermediary substance that mediates between the harmful platinum ions and the blood system. These particles bind platinum ions through their protein and amino acid content, converting the toxic free platinum ions into bound complexes that can be safely removed, thus mediating the elimination process.
3Quantity of substance
If additional molecules or drugs are used to eliminate platinum, then platinum removal may be achieved, but functioning of essential organs such as kidney or liver may be worsened
Solution Approach 1:
The patent uses disposable eggshell membrane particles that are introduced into the blood, bind platinum ions, and are then removed in the apheresis process. These particles perform their function of platinum binding and are then discarded, avoiding the need for long-term presence of potentially organ-toxic drugs in the body.
Solution Approach 2:
The eggshell membrane particles possess inherent platinum-binding capability through their natural protein and amino acid composition, requiring no additional activation or conversion. They self-service by automatically binding platinum ions upon contact, eliminating the need for complex drug administration and metabolic processing that could harm organs.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Effectively reduces residual platinum in cancer patients' blood post-chemotherapy by adsorption, minimizing toxic side effects on organs like the kidney and liver.
Implementation Method 1
which by means of an ion exchange, creates a bond that favours the adsorption union between the platinum molecule and the egg membrane particles
Implementation Method 2
creates a bond that favours the adsorption union between the platinum molecule and the egg membrane particles
Data Source
Figure 1~2
AI summary
The invention relates to a therapeutic apheresis filter for eliminating heavy metals in blood and especially residual platinum in cancer patients after chemotherapy treatment. The filter comprises a casing (1) that can be coupled to an extracorporeal apheresis device and that has inlet and outlet openings (11a, 12a) for circulating therein blood or plasma extracted from a patient and that delimits a cavity containing a biomaterial (3), made up of granulated or powdered egg membrane particles for retaining the heavy metal molecules inside the filter by adsorption. The invention further comprises a method using the apheresis filter with egg membrane as a biomaterial to eliminate heavy metals in blood.