EIBS Detection Probe for Early Abnormal Tissue Identification
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Solution Overview
Problem
Current methods for detecting abnormal tissues, such as tumors or lesions, often require testing the tissue itself and can only detect abnormalities after they have grown sufficiently, making it difficult to identify early changes in tissue development, especially in the case of cancerous tissues.
Innovation Solution
The development of a method and apparatus using broadband light to detect early increases in microvascular blood supply (EIBS) in tissues near or preceding lesions, allowing for the identification of abnormal tissues through optical measurements without the need for biopsy or extensive preparation, utilizing a fiber-optic probe with polarization-gated technology to analyze blood content and flow in superficial and subsuperficial tissues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional methods are used to detect abnormal tissue, then the detection can only be performed after the tissue has grown sufficiently large, but this makes it difficult to detect early changes in tissue development
Solution Approach 1:
The patent applies preliminary action by detecting early increases in microvascular blood supply (EIBS) in tissues before abnormal lesions develop. The system identifies precancerous changes by measuring blood content in microvasculature of adjacent normal-appearing tissues, enabling detection before traditional methods can identify visible abnormalities.
Solution Approach 2:
The patent uses microvascular blood supply as an intermediary marker to detect early tissue abnormalities. Instead of directly detecting abnormal tissue, the system measures blood content in microvasculature as an intermediate indicator that precedes visible tissue changes, allowing earlier detection.
2Measurement precision
If biopsy or extensive preparation is performed to detect abnormal tissue, then detection accuracy may improve, but the complexity and invasiveness of the procedure increases
Solution Approach 1:
The patent replaces mechanical biopsy procedures with optical measurement systems. Instead of physically extracting tissue samples, the system uses light interaction with microvascular blood to detect abnormalities, eliminating the need for invasive procedures while maintaining detection accuracy.
Solution Approach 2:
The patent enables the tissue to reveal its abnormal state through its own optical properties. The microvascular blood supply naturally interacts with light in detectable ways, allowing the tissue to provide diagnostic information without external intervention or preparation.
3Reliability
If traditional detection methods are used, then only established tumors can be detected, but this misses precancerous conditions and early-stage abnormalities
Solution Approach 1:
The system performs preliminary detection by identifying EIBS in tissues before cancerous lesions develop. It captures early physiological changes in microvascular blood supply that occur during precancerous transitions, preserving information that would be lost with traditional detection methods.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the detection of abnormal tissues, including precancerous conditions, at an early stage by identifying EIBS in tissues outside the lesion, providing a directional indication for further testing and potentially reducing the miss rate of adenomas during colonoscopy, with high sensitivity and specificity, even before traditional markers are present.
Implementation Method 1
detecting interacted light that results from the step of illuminating the location, wherein the detected interacted light is obtained substantially from light scattered from blood in the microvasculature
Data Source
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AI summary
The present invention, in one aspect, relates to a method of and apparatus for examining a target for tumors or lesions using what is referred to as "Early Increase in microvascular Blood Supply" (EIBS) that exists in tissues that are close to, but are not themselves, the abnormal tissue and in tissues that precede the development of such lesions or tumors. While the abnormal tissue can be a lesion or tumor, the abnofmal tissue can also be tissue that precedes formation of a lesion or tumor, such as a precancerous adenoma, aberrant crypt foci, tissues that precede the development of dysplastic lesions that themselves do not yet exhibit dysplastic phenotype, and tissues in the vicinity of these lesions or pre-dysplastic tissues.